Results 1 to 10 of about 4,011,919 (357)

Advances in the structures, mechanisms and targeting of molecular chaperones [PDF]

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +3 more sources

Molecular chaperones and Parkinson's disease

Neurobiology of Disease, 2021
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs). Mutations in PD-related genes lead to neuronal pathogenesis through various
Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang   +7 more
doaj   +2 more sources

Molecular chaperones in stroke-induced immunosuppression [PDF]

Neural Regeneration Research, 2023
Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.
Haoduo Qiao, Qing Xu, Yunfei Xu, Yao Zhao, Nina He, Jie Tang, Jie Zhao, Ying Liu   +7 more
doaj   +2 more sources

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space. [PDF]

Nat Cell Biol, 2023
Mitochondria are complex organelles with different compartments, each harbouring their own protein quality control factors. While chaperones of the mitochondrial matrix are well characterized, it is poorly understood which chaperones protect the ...
Adriaenssens E, Asselbergh B, Rivera-Mejías P, Bervoets S, Vendredy L, De Winter V, Spaas K, de Rycke R, van Isterdael G, Impens F, Langer T, Timmerman V.   +11 more
europepmc   +2 more sources

The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90. [PDF]

Int J Mol Sci, 2022
Breast cancer (BC) is a major public health problem, with key pieces of information needed for developing preventive and curative measures still missing.
Alberti G, Vergilio G, Paladino L, Barone R, Barone R, Cappello F, Conway de Macario E, Macario AJL, Bucchieri F, Rappa F.   +9 more
europepmc   +2 more sources

Redefining Molecular Chaperones as Chaotropes [PDF]

Frontiers in Molecular Biosciences, 2021
Molecular chaperones are the key instruments of bacterial protein homeostasis. Chaperones not only facilitate folding of client proteins, but also transport them, prevent their aggregation, dissolve aggregates and resolve misfolded states.
Jakub Macošek, Guillaume Mas, Sebastian Hiller   +2 more
doaj   +2 more sources

Molecular chaperones and hypoxic-ischemic encephalopathy

Neural Regeneration Research, 2017
Hypoxic-ischemic encephalopathy (HIE) is a disease that occurs when the brain is subjected to hypoxia, resulting in neuronal death and neurological deficits, with a poor prognosis.
Cong Hua, Wei-na Ju, Hang Jin, Xin Sun, Gang Zhao   +4 more
doaj   +2 more sources

Beneficial Handling of Molecular Chaperones (Chaperonotherapy) in Glioblastoma and Neuroblastoma: Novel Therapeutic Targets or Potential Agents? [PDF]

Cells
Molecular chaperones, especially Heat Shock Proteins (HSPs), play complex, context-dependent roles in cancer, particularly in nervous system (NS) tumors like glioblastoma (GBM) and neuroblastoma (NB).
Maria Antonella Augello, Nima Shadan, Giuseppa D’Amico, Rosario Barone, Celeste Caruso Bavisotto, Federica Scalia, Alessandra Maria Vitale   +6 more
doaj   +2 more sources

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

Nature Communications, 2016
Molecular chaperones are recognized to interfere with protein aggregation, yet the underlying mechanisms are largely unknown. Here, the authors develop a kinetic model that reveals the variety of distinct microscopic mechanisms through which molecular ...
Paolo Arosio, Thomas C. T. Michaels, Sara Linse, Cecilia Månsson, Cecilia Emanuelsson, Jenny Presto, Jan Johansson, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles   +9 more
doaj   +2 more sources

Gymnastics of Molecular Chaperones [PDF]

Molecular Cell, 2010
Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
Matthias P. Mayer
openalex   +3 more sources