Results 41 to 50 of about 5,665,898 (300)

Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer

Frontiers in Immunology, 2022
BackgroundPancreatic cancer (PC) is one of the most lethal malignancies and carries a dismal mortality and morbidity. Four types of RNA modification (namely m6A, m1A, APA and A-to-I) could be catalyzed by distinct enzymatic compounds (“writers ...
Wenzhe Gao, Dongjie Chen, Dongjie Chen, Dongjie Chen, Dongjie Chen, Jixing Liu, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu   +12 more
doaj   +1 more source

Molecular classification of gastric cancer

Annals of Oncology, 2016
Gastric cancer (GC), a heterogeneous disease characterized by epidemiologic and histopathologic differences across countries, is a leading cause of cancer-related death. Treatment of GC patients is currently suboptimal due to patients being commonly treated in a uniform fashion irrespective of disease subtype.
N-Y, Chia, P, Tan
openaire   +2 more sources

Novel Classification of Mono-Molecular Odorants using Standardized Semantic Profiles [PDF]

, 2022
Odorants are typically classified by specially trained individuals using subjective verbal scent descriptors. Herein, we used natural language processing to develop standardized semantic profiles of mono-molecular odorants.
Alexander, Tropsha, Andrew, Thieme, Daniel, Korn, Vinicius, Alves, Eugene, Muratov   +4 more
core   +1 more source

The association of molecular classification with fertility-sparing treatment of atypical endometrial hyperplasia and endometrial cancer: a retrospective study

Frontiers in Oncology
BackgroundTo evaluate whether molecular classification was associated with treatment response and recurrence in women with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer (EC) treated with progestin.MethodsA retrospective ...
Yuanyuan Wang, Yuanyuan Wang, Tianjiao Lai, Danxia Chu, Jing Bai, Shuping Yan, Ruixia Guo   +6 more
doaj   +1 more source

Pulmonary Large-Cell Neuroendocrine Carcinoma: Therapeutic Challenges and Opportunities

Forum of Clinical Oncology, 2020
Pulmonary large cell neuroendocrine carcinoma (P-LCNEC) is a rare, poorly differentiated, non-small cell malignancy within the spectrum of neuroendocrine tumors (NETs) of the lung.
Ioannidis Georgios
doaj   +1 more source

Review of current classification, molecular alterations, and tyrosine kinase inhibitor therapies in myeloproliferative disorders with hypereosinophilia

, 2013
Violaine Havelange,1,2 Jean-Baptiste Demoulin1 1de Duve Institute, Université catholique de Louvain, Brussels, Belgium; 2Department of Hematology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium ...
Havelange, Violaine, Demoulin JB, Havelange V, Demoulin, Jean-Baptiste   +3 more
core   +1 more source

The Role of Immunohistochemistry as a Surrogate Marker in Molecular Subtyping and Classification of Bladder Cancer

Diagnostics
Background/Objectives: Bladder cancer (BC) is a highly heterogeneous disease, presenting clinical challenges, particularly in predicting patient outcomes and selecting effective treatments.
Tatiana Cano Barbadilla, Martina Álvarez Pérez, Juan Daniel Prieto Cuadra, Mª Teresa Dawid de Vera, Fernando Alberca-del Arco, Isabel García Muñoz, Rocío Santos-Pérez de la Blanca, Bernardo Herrera-Imbroda, Elisa Matas-Rico, Mª Isabel Hierro Martín   +9 more
doaj   +1 more source

Prognostic Significance and Molecular Classification of Triple Negative Breast Cancer: A Systematic Review. [PDF]

Eur J Breast Health
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer defined by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression.
Aziz OBA.
europepmc   +2 more sources

Low-Grade Endometrial Cancer with Abnormal p53 Expression as a Separate Clinical Entity: Insights from RNA Sequencing and Immunohistochemistry

Diagnostics
Background: A molecular classification of endometrial cancer was developed based on an analysis of The Cancer Genome Atlas. In this classification, the group characterized by abnormal p53 immunohistochemical expression showed the poorest prognosis ...
Kazuhisa Hachisuga, Minoru Kawakami, Hiroshi Tomonobe, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Hideaki Yahata, Yoshinao Oda, Kiyoko Kato   +11 more
doaj   +1 more source

Harnessing DLL3 inhibition: From old promises to new therapeutic horizons

Frontiers in Medicine, 2022
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a high relapse rate, limited therapeutic options, and poor prognosis. The combination of chemotherapy and immune-checkpoint inhibitors brings a new therapeutic era, although the ...
Diego Luigi Cortinovis, Diego Luigi Cortinovis, Francesca Colonese, Maria Ida Abbate, Luca Sala, Marco Meazza Prina, Nicoletta Cordani, Elisa Sala, Stefania Canova   +8 more
doaj   +1 more source