Results 181 to 190 of about 766,908 (329)

A FRET-Based Sensor Reveals Large ATP Hydrolysis–Induced Conformational Changes and Three Distinct States of the Molecular Motor Myosin [PDF]

, 2000
William M. Shih, Zygmunt Gryczyński, Joseph R. Lakowicz, James A. Spudich   +3 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

True molecular conformation and structure determination by three-dimensional electron diffraction of PAH by-products potentially useful for electronic applications. [PDF]

IUCrJ, 2023
Andrusenko I, Hall CL, Mugnaioli E, Potticary J, Hall SR, Schmidt W, Gao S, Zhao K, Marom N, Gemmi M.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface. [PDF]

Bone Res, 2021
Long Y, Cheng X, Jansen JA, Leeuwenburgh SGC, Mao J, Yang F, Chen L.   +6 more
europepmc   +1 more source

2P167 Conformational changes of flagellar axonemes of Chlamydomonas studied by x-ray fiber diffraction analysis(Molecular motors,Poster Presentations)

, 2007
Shiori Toba, Hiroyuki Iwamoto, Hitoshi Sakakibara, Kazuhiro Oiwa   +3 more
openalex   +2 more sources

Electrically modulated photothermal force microscopy for revealing molecular conformation changes during polarization switching at the nanoscale. [PDF]

Nat Commun
Yao S, Jiang H, Wen J, Shu D, Xu C, Zhu W, Zhang X, Zheng Y.   +7 more
europepmc   +1 more source

Exploring the Molecular Conformation Space by Soft Molecule-Surface Collision. [PDF]

J Am Chem Soc, 2020
Anggara K, Zhu Y, Delbianco M, Rauschenbach S, Abb S, Seeberger PH, Kern K.   +6 more
europepmc   +1 more source

1P582 Explicit and GB/SA solvents : each with two different force fields in multicanonical conformational sampling of 25-residue polypeptide(27. Molecular dynamics simulation,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Daisuke Mitomo, Yukihisa S. Watanabe, Narutoshi Kamiya, Junichi Higo   +3 more
openalex   +2 more sources