Results 221 to 230 of about 4,904,917 (369)

Conformation of Polyalanine and Polyglycine Dications in the Gas Phase: Insight from Ion Mobility Spectrometry and Replica-Exchange Molecular Dynamics

, 2010
Florian Albrieux, F. Calvo, Fabien Chirot, Aleksey Vorobyev, Yury O. Tsybin, Valéria Lepère, Rodolphe Antoine, Jérôme Lemoine, Philippe Dugourd   +8 more
openalex   +2 more sources

Molecular imaging of telomerase and the enzyme activity-triggered drug release by using a conformation-switchable nanoprobe in cancerous cells [PDF]

, 2018
Hai Shi, Tao Gao, Shi Liu, Tianshu Chen, Yang Xiang, Yuanyang Li, Genxi Li   +6 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Insight into the stabilization mechanism of rice protein amyloid fibrils modification on soy protein isolate gels: Gel properties, microstructure, and molecular conformation. [PDF]

Food Chem X
Ma J, Wang L, Pan D, Wang K, Huo J, Ma X, Lu B, Yu X, Xiao Z.   +8 more
europepmc   +1 more source

Activation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanism [PDF]

, 2009
Dariusz Ekonomiuk, Amedeo Caflisch
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

EC-Conf: A ultra-fast diffusion model for molecular conformation generation with equivariant consistency. [PDF]

J Cheminform
Fan Z, Yang Y, Xu M, Chen H.
europepmc   +1 more source

EARTHMOVER-BASED MANIFOLD LEARNING FOR ANALYZING MOLECULAR CONFORMATION SPACES. [PDF]

Proc IEEE Int Symp Biomed Imaging, 2020
Zelesko N, Moscovich A, Kileel J, Singer A.   +3 more
europepmc   +1 more source

Synthesis, Conformational Analysis, Antioxidant and Enzyme Inhibition Activity, Molecular Docking, and DFT Studies of New Chiral Hydrazide–Hydrazone Derivatives [PDF]

Şenel Teke Tunçel, Yusuf Sıcak, M. Oluş Özbek, Abdullahi İbrahim Uba, Ayşegül Karaküçük‐İyidoğan, Emine Elçin Oruç‐Emre   +5 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source