Results 41 to 50 of about 680,341 (256)

Correlation of TIMP1-MMP2/MMP9 Gene Expression Axis Changes with Treatment Efficacy and Survival of NSCLC Patients

Biomedicines, 2023
In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in the microenvironment, including the extracellular matrix (ECM), which is not only a scaffold for cells, but also a reservoir of cytokines, chemokines and
Jacek Pietrzak, Agnieszka Wosiak, Dagmara Szmajda-Krygier, Rafał Świechowski, Mariusz Łochowski, Milena Pązik, Ewa Balcerczak   +6 more
doaj   +1 more source

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source

New and Improved Diagnostics for Detection of Drug-Resistant Pulmonary Tuberculosis. [PDF]

, 2011
PURPOSE OF REVIEW: Tuberculosis (TB) remains a global emergency and continues to kill 1.7 million people globally each year. Drug-resistant TB is now well established throughout the world and most TB patients are not being screened for drug resistance ...
Affolabi, Albert, Banerjee, Blakemore, Boehme, Brossier, Bwanga, Caws, Coronel, Drews, Ellner, Ellner, Farnia, Fears, Garza-González, Gupta, Helb, Hillemann, Kiet, Kim, Lemaire, Lin, Ling, Martin, Martin, Martin, Migliori, Migliori, Minion, Morcillo, Neonakis, Nicol, Pai, Palomino, Piersimoni, Sandgren, Sohn, Van Rie, Visalakshi, Visalakshi, Wallis, Wright   +41 more
core   +1 more source

Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population

International Journal for Parasitology: Drugs and Drug Resistance, 2023
Background: Anthelmintic resistance to benzimidazole has been detected in the canine hookworm, Ancylostoma caninum. Benzimidazole resistance is believed to have developed originally in greyhounds, but has also been detected in non-greyhound pet dogs. The
Christian M. Leutenegger, Cecilia E. Lozoya, Jeffrey Tereski, Christian Savard, Jennifer Ogeer, Rene Lallier   +5 more
doaj   +1 more source

Medical diagnostics using designed molecules with sense and logic [PDF]

, 2013
Luminescent molecules responsive to cations, anions and even small molecules can be designed with the appropriate selectivity and sensitivity for monitoring physiological and pathological levels of analytes.
Cardona, Mario, Farrugia, Kristina, Magri, David C.   +2 more
core   +1 more source

Estimation of CYP3A4*1B single nucleotide polymorphism in patients with recurrent Major Depressive Disorder

Molecular Genetics & Genomic Medicine, 2019
Background Major depression is the most common mental illness in the world. Failures in treatment may occur due to the presence of a subtype of depression called TRD (Treatment‐ Resistant Depression).
Rafał Świechowski, Agnieszka Jeleń, Marek Mirowski, Monika Talarowska, Piotr Gałecki, Jacek Pietrzak, Damian Wodziński, Ewa Balcerczak   +7 more
doaj   +1 more source

Long-read based de novo assembly of low-complexity metagenome samples results in finished genomes and reveals insights into strain diversity and an active phage system

BMC Microbiology, 2019
Background Complete and contiguous genome assemblies greatly improve the quality of subsequent systems-wide functional profiling studies and the ability to gain novel biological insights. While a de novo genome assembly of an isolated bacterial strain is
Vincent Somerville, Stefanie Lutz, Michael Schmid, Daniel Frei, Aline Moser, Stefan Irmler, Jürg E. Frey, Christian H. Ahrens   +7 more
doaj   +1 more source

The optimal vaccination strategy to control COVID-19: a modeling study in Wuhan City, China

Infectious Diseases of Poverty, 2021
Background Reaching optimal vaccination rates is an essential public health strategy to control the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to simulate the optimal vaccination strategy to control the disease by developing an age ...
Ze-yu Zhao, Yan Niu, Li Luo, Qing-qing Hu, Tian-long Yang, Mei-jie Chu, Qiu-ping Chen, Zhao Lei, Jia Rui, Cheng-long Song, Sheng-nan Lin, Yao Wang, Jing-wen Xu, Yuan-zhao Zhu, Xing-chun Liu, Meng Yang, Jie-feng Huang, Wei-kang Liu, Bin Deng, Chan Liu, Zhuo-yang Li, Pei-hua Li, Yan-hua Su, Ben-hua Zhao, Wen-long Huang, Roger Frutos, Tian-mu Chen   +26 more
doaj   +1 more source

Development of rapid, automated diagnostics for infectious disease: advances and challenges [PDF]

, 2009
The last 2 years has seen an exponential rise in the amount of research funding made available for the development of rapid diagnostic devices for infectious agents of medical importance. This review reports on several such projects.
Ince, J, McNally, A
core   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source