Results 201 to 210 of about 9,026,651 (342)

The Molecular Evolution of Xenobiotic Metabolism and Resistance in Chelicerate Mites.

Annual Review of Entomology, 2016
T. Van Leeuwen, W. Dermauw
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Molecular Evolution and Phylogeography of the Crimean-Congo Hemorrhagic Fever Virus. [PDF]

Viruses
Iglesias-Rivas P, González-Vázquez LD, Arenas M.   +2 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Molecular evolution of the Wood-Ljungdahl pathway and the reductive glycine pathway in <i>Desulfobacterota</i>. [PDF]

Front Microbiol
Wakashima T, Kume K, Chiba Y.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Improved genome assembly of whale shark, the world's biggest fish: revealing intragenomic heterogeneity in molecular evolution. [PDF]

Gigascience
Kawaguchi YW, Matsumoto R, Kuraku S.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular Evolution of the NLR Gene Family Reveals Diverse Innate Immune Strategies in Bats. [PDF]

Biomolecules
Liu G, Han F, Guo X, Yang L, Du N, Zhao X, Zhang C, Peng J, Zhang K, Feng J, Liu Y.   +10 more
europepmc   +1 more source

Molecular evolution of the lysophosphatidic acid acyltransferase (LPAAT) gene family.

Molecular Phylogenetics and Evolution, 2016
A. P. Körbes, F. Kulcheski, R. Margis, M. Margis-Pinheiro, A. Turchetto-Zolet   +4 more
semanticscholar   +1 more source