Results 51 to 60 of about 4,885,439 (330)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species

iScience, 2022
Summary: Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains controversial in ecological model systems.
Nathalie Feiner, Reinder Radersma, Louella Vasquez, Markus Ringnér, Björn Nystedt, Amanda Raine, Elmar W. Tobi, Bastiaan T. Heijmans, Tobias Uller   +8 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Acinetobacter baumannii biofilm was inhibited by tryptanthrin through disrupting its different stages and genes expression

iScience
Summary: Biofilm formation plays a significant role in antibiotic resistance, necessitating the search for alternative therapies against biofilm-associated infections.
Tingting Guo, Na Zhou, Liying Yang, Zichen Wang, Changchao Huan, Tao Lin, Guangyu Bao, Jian Hu, Guocai Li   +8 more
doaj   +1 more source

Genetic and functional analysis reveals TENM4 contributes to schizophrenia

iScience, 2021
Summary: TENM4, encoding a member of the teneurin protein family, is a risk gene shared by many types of mental diseases and is implicated in neuronal plasticity and signaling.
Xin Yi, Minzhe Li, Guang He, Huihui Du, Xingwang Li, Dongmei Cao, Lu Wang, Xi Wu, Fengping Yang, Xu Chen, Lin He, Yong Ping, Daizhan Zhou   +12 more
doaj   +1 more source

Molecular genetics of hypospadias and cryptorchidism recent developments

Clinical Genetics, 2018
During the last decade, a tremendous amount of work has been devoted to the study of the molecular genetics of isolated hypospadias and cryptorchidism, two minor forms of disorders of sex development (DSD).
N. Kalfa, L. Gaspari, M. Ollivier, P. Philibert, A. Bergougnoux, F. Paris, C. Sultan   +6 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular Genetics of Gastric Adenocarcinoma

Proceedings of Singapore Healthcare, 2010
Gastric carcinoma is the second leading cause of cancer deaths in the world. Its aetiology is closely linked to the bacterial pathogen Helicobacter pylori which is believed to induce a state of chronic inflammation that predisposes to a cascade of ...
Alvin Kim Hock Eng MMed (Surgery), FRCSEd, Oi Lian Kon FRCPC, MD   +1 more
doaj   +1 more source

Molecular Genetics of Turcot’s Syndrome

Pediatric Neurology Briefs, 1995
Genetic abnormalities in 13 of 14 families with concurrent primary brain tumors and multiple colorectal adenomas (Turcot’s syndrome) are reported from the Johns Hopkins University School of Medicine and other centers.
J Gordon Millichap
doaj   +1 more source