Results 221 to 230 of about 3,265,759 (283)

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation. [PDF]

Nat Commun
Langousis G, Gainza P, Hunkeler M, Kapsitidou D, Donckele EJ, Annunziato S, Wiedmer L, Jones KFM, DeMarco B, Quan C, Bunker RD, Lumb KJ, Fasching B, Castle JC, Townson SA, Bonenfant D.   +15 more
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Molecular Glue-like Degraders of TEM β-Lactamases by Periplasmic Protease DegP

Taylor EK, Barbosa PS, Kadambi T, Eisele F, Moura ECCM, Walsh TR, Isom GL, Lanyon-Hogg T.   +7 more
europepmc   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology. [PDF]

J Am Chem Soc
Gray JL, Xiao Z, Rogga VV, Zhang X, Tate EW.   +4 more
europepmc   +1 more source

Thermochemical Core–Shell Architecturing of Si‐SWCNT Composites for High‐Performance Li‐Ion Battery Anodes

Advanced Science, EarlyView.
A thermochemically engineered core–shell Si architecture is developed through the controlled evolution of a SWCNT‐coated Mg2Si precursor. The process simultaneously generates a nanoporous Si shell for strain accommodation and Li+ transport, a chemically anchored SiC interfacial layer for robust mechanical and electrical coupling, and a Mg‐containing Si
Dong Gyun Hong, Byeong Guk Kim, Jung‐Hyeok Park, Sunwoo Lee, Donghwi Cho, Jaeik Hyun, Ki‐Hun Nam, Youngoh Kim, Geon‐Woong Lee, Sunhye Yang, Seung Yol Jeong, Myungwoo Choi   +11 more
wiley   +1 more source

A Superstrong and Ultratough Stretchable Electronic Conductor With Ultradurable Strain‐Insensitive Electromechanical Performance

Advanced Science, EarlyView.
We report a superstrong, ultratough, and fatigue‐resistant stretchable electronic conductor (SEC) integrating a viscoplastic quasi‐solid LM‐Ag alloy with a supramolecular elastomer. Unlike conventional LM, the alloy exhibits thixotropic flow, reduced surface tension, and enhanced interfacial interactions with the elastomer.
Yuxing Shan, Dong Lei, Chengzhi Huang, Chunhong Gong, Jingwei Zhang, Xiaokong Liu   +5 more
wiley   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Synthesis and Structure-Activity Relationships of CRBN-Recruiting ZBTB11 Molecular Glue Degraders. [PDF]

J Med Chem
Jiang J, Tran NL, Svendsen E, Wang ES, Ferguson FM.   +4 more
europepmc   +1 more source

Gate Metal‐Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems

Advanced Science, EarlyView.
Intrinsically stretchable OECTs enable bifunctional operations via gate engineering. Polarizable Ag/AgCl gates provide volatile sensing, while Au gates enable non‐volatile memory. The SEBS‐blended channel maintains performance under strain, supporting reliable signal transduction.
Jiyong Yoon, Jaepyo Jang, Hyunjin Jung, Duhwan Seong, Daeun Kim, Yewon Jeon, Ja Hoon Koo, Sang Min Won, Donghee Son   +8 more
wiley   +1 more source