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Photoswitchable Molecular Glue for DNA
Journal of the American Chemical Society, 2007DNA molecular glue is a small synthetic ligand that can adhere two single-stranded DNAs that do not spontaneously hybridize with each other. For reversible control of DNA hybridization by an external light stimulus, we have developed a photoswitchable molecular glue for DNA.
Chikara, Dohno +2 more
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Integrins: The Molecular Glue of life
Hospital Practice, 2000The molecular interactions responsible for cellular adhesion, either to other cells or to extracellular matrix, are now known to be complex, well orchestrated, and under sophisticated control. Among the participating molecules, integrins serve a notably broad range of biologic processes, including platelet aggregation and leukocyte extravasation.
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Molecular glues as potential GPCR therapeutics
Biochemical Pharmacology"Molecular Glues" are defined as small molecules that can either be endogenous or synthetic which promote interactions between proteins at their interface. Allosteric modulators, specifically GPCR allosteric modulators, can promote both the association and the dissociation of a given receptor's transducer but accomplishes this "at a distance" from the ...
Krumm, Brian E, Roth, Bryan L
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Routes to molecular glue degrader discovery
Trends in Biochemical SciencesMolecular glue degraders (MGDs) represent a unique class of targeted protein degradation (TPD) modalities. By facilitating protein-protein interactions between E3 ubiquitin ligases and neo-substrates, MGDs offer a novel approach to target previously undruggable or insufficiently drugged disease-causing proteins. Here, we present an overview of recently
Yanfen Liu +3 more
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Discovery of a molecular glue for EGFR degradation
OncogeneAberrant expression of epidermal growth factor receptor (EGFR) plays a critical role in the pathogenesis of various tumors, potentially representing a target for therapeutic intervention. Nonetheless, EGFR remains a challenging protein to target pharmacologically in triple-negative breast cancer (TNBC).
Hairui Wang +13 more
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International Journal of Biological Macromolecules
Molecular glues (MGs) are a new class of small molecules that can modulate protein-protein interactions, leading to selective protein degradation, stabilization or activation. This breakthrough opens new possibilities for treating diseases such as cancer and neurodegenerative disorders.
Khaledian, Maisam +8 more
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Molecular glues (MGs) are a new class of small molecules that can modulate protein-protein interactions, leading to selective protein degradation, stabilization or activation. This breakthrough opens new possibilities for treating diseases such as cancer and neurodegenerative disorders.
Khaledian, Maisam +8 more
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Expanding the reach of molecular glue degraders
ScienceAn epitope-centric screening approach widens the neosubstrate landscape for targeted protein ...
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Crbn-based molecular Glues: Breakthroughs and perspectives
Bioorganic & Medicinal ChemistryCRBN is a substrate receptor for the Cullin Ring E3 ubiquitin ligase 4 (CRL4) complex. It has been observed that CRBN can be exploited by small molecules to facilitate the recruitment and ubiquitination of non-natural CRL4 substrates, resulting in the degradation of neosubstrate through the ubiquitin-proteasome system.
Juzeng An, Xiaojun Zhang
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