Results 231 to 240 of about 3,265,759 (283)

Property-Based Optimization of Cereblon-Based Molecular Glue Degraders. [PDF]

ACS Med Chem Lett
Jones LH.
europepmc   +1 more source

A Glutathione S-Transferase Pi Molecular Glue Tethers Splicing Factors and Remodels Cell Metabolism. [PDF]

J Am Chem Soc
Leace DM, Ware ML, Murtagh O, Tsai HK, Chang CY, Hsu KL.   +5 more
europepmc   +1 more source

Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1. [PDF]

Asian J Pharm Sci
Cheng B, Wang Y, Hong Y, Zhou Y, Peng X, Chen J, Zeng C.   +6 more
europepmc   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders. [PDF]

Adv Sci (Weinh)
Lin Q, Liu W, Lu W, Zhao M, Cao L, Li Z, Wang J, Xu X, Wu H.   +8 more
europepmc   +1 more source

Molecular glue binding behavior of phosphoantigens to alpaca butyrophilins. [PDF]

J Biol Chem
Liu C, Yi S, Zhang M, Chen CC, Liu Y, Zhang Z, Guo RT, Yang Y.   +7 more
europepmc   +1 more source

Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor

Banerjee N, Ganguly M, Reyaz A, Mishra S, Dalal A, Guo X, Qiu X, Meyrath M, Palmer CB, Guo H, Song S, Sinha S, Roy N, Mukherjee D, Tiwari D, Yadav MK, Chevigne A, Robinson CV, Chen X, Banerjee R, Shukla AK.   +20 more
europepmc   +1 more source

Molecular glue concept solidifies

Nature Chemical Biology, 2019
Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.
Kheewoong Baek, Brenda A. Schulman
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Haven't got a glue: Protein surface variation for the design of molecular glue degraders

Cell Chemical Biology, 2021
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent degradation of the recruited protein. In recent years, serendipitous discoveries revealed that some preclinical and clinical compounds already work as molecular glue degraders, with ...
Zuzanna Kozicka
exaly   +4 more sources

Prospecting for molecular glues

Nature Chemical Biology, 2020
Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.
Willem, den Besten, J Russell, Lipford
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Targeting cancer with molecular glues

Science, 2023
Molecular glues suppress the active form of the oncogenic protein ...
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