Results 41 to 50 of about 3,265,759 (283)

A theranostic abscisic acid-based molecular glue

, 2023
Molecular glues, capable of selectively controlling the interactions between specific pairs or groups of proteins and the associated downstream effects, have become a promising strategy for manipulating cellular functions and developing novel therapies ...
Liang, F.-S., Chen, J., Zeng, F., Xu, H., Wang, W., Nguyen, H.T.X., Yang, M.   +6 more
core   +1 more source

Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?

Frontiers in Molecular Neuroscience
Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of ...
Sandra Kuemper, Andrew G. Cairns, Kristian Birchall, Zhi Yao, Jonathan M. Large   +4 more
doaj   +1 more source

Defining molecular glues with a dual-nanobody cannabidiol sensor

Nature Communications, 2022
Molecular glue has been used as a broad term describing a class of protein interaction-promoting compounds. Here, the authors outline two unifying thermodynamic features to formally define molecular glues and guide their prospective discovery.
Shiyun Cao, Shoukai Kang, Haibin Mao, Jiayu Yao, Liangcai Gu, Ning Zheng   +5 more
doaj   +1 more source

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders. [PDF]

Angew Chem Int Ed Engl
Zhuang Z, Byun WS, Kozicka Z, Donovan KA, Dwyer BG, Thornhill AM, Jones HM, Jiang Z, Zhu X, Fischer ES, Thomä NH, Gray NS.   +11 more
europepmc   +2 more sources

Machine learning proteochemometric models for Cereblon glue activity predictions

Artificial Intelligence in the Life Sciences
Targeted protein degradation (TPD) is a rapidly developing drug discovery technique with unique efficacy and target scope stemming from its degradation-based activity.
Francis J. Prael, III, Jiayi Cox, Noé Sturm, Peter Kutchukian, William C. Forrester, Gregory Michaud, Jutta Blank, Lingling Shen, Raquel Rodríguez-Pérez   +8 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Hygroscopic compounds in spider aggregate glue remove interfacial water to maintain adhesion in humid conditions

Nature Communications, 2018
Spider aggregate glue avoids failure in humid environments but the fundamental mechanism behind it is still unknown. Here, the authors demonstrate that humidity-dependent structural changes of glycoproteins and sequestering of liquid water by low ...
Saranshu Singla, Gaurav Amarpuri, Nishad Dhopatkar, Todd A. Blackledge, Ali Dhinojwala   +4 more
doaj   +1 more source

Natural glues and fouling management by interfering with glue curing

Journal of Agricultural and Marine Sciences, 2015
Multidisciplinary approaches and modern technology provide insights to glue curing that are stimulatingand controversial. Our team applies classic and modern theory and techniques to the study of barnacle glue.
Daniel Rittschof, Tara Essock-Burns, Gary Dickinson, S. Zmina, N. Alberman   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Degradation of Glue in Lead Electrorefining

Journal of MMIJ, 2023
Surface morphology of lead deposits from H2SiF6-PbSiF6 electrolyte containing an animal glue was investigated by means of the periodic galvanostatic electrolysis and SEM-EDS observation. The weight average molecular weight of the glue was also determined
Toshiki OKUDERA, Hidehiro SEKIMOTO
doaj   +1 more source