Results 31 to 40 of about 3,265,759 (283)

Sticking It to Cancer with Molecular Glue for SHP2 [PDF]

Cancer Cell, 2016
Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.
Hao, Ran, Ryouhei, Tsutsumi, Toshiyuki, Araki, Benjamin G, Neel   +3 more
openaire   +2 more sources

Chemical–biological approaches for the direct regulation of cell–cell aggregation

Aggregate, 2022
Cell–cell aggregation is one of the most well‐known modes of intercellular communication. The aggregation also plays a vital role in the formation of multicellularity, thus manipulating the growth and development of organisms.
Jia‐Yi Ma, Ya‐Xin Wang, Yan Huang, Yi Zhang, Yun‐Xi Cui, De‐Ming Kong   +5 more
doaj   +1 more source

glue-viz/glue: v1.14.1

, 2023
<p><!-- Release notes generated using configuration in .github/release.yml at main --></p> <h2>What's Changed</h2> <h3>Bug Fixes</h3> <ul> <li>Fix bug when changing the number of bins on a histogram ...
Chris Beaumont, Jon Carifio, Thomas Robitaille, Simon Conseil, Yuval Langer, Maarten Breddels, Nabil Freij, Dan D'Avella, Peter Teuben, ejeschke, Robin Wilson, Brigitta Sipőcz, Jonathan Foster, P. L. Lim, Stuart Mumford, Adam Ginsburg, Brett M. Morris, Jonathan Eisenhamer, Derek Homeier, specmicp, Robel Geda, Jeffrey SubbaRao, Will Dampier, Adrian Price-Whelan, Kyle Conroy, Camellia Magness, Clément Robert, Jesse Averbukh, Ricky O'Steen, John ZuHone   +29 more
core   +1 more source

Calixarene-mediated assembly of a small antifungal protein

IUCrJ, 2019
Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more proteins bind simultaneously ...
Jimi M. Alex, Martin L. Rennie, Sylvain Engilberge, Gábor Lehoczki, Hajdu Dorottya, Ádám Fizil, Gyula Batta, Peter B. Crowley   +7 more
doaj   +1 more source

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

eLife, 2020
Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. Here, we report a new molecular glue HQ461 discovered by high-throughput screening. Using loss-
Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han   +11 more
doaj   +1 more source

Hypersensitive-like response in Brassica plants is specifically induced by molecules from egg-associated secretions of cabbage white butterflies

Frontiers in Ecology and Evolution, 2023
Plants perceive and respond to herbivore insect eggs. Upon egg deposition on leaves, a strong hypersensitive response (HR)-like cell death can be activated leading to egg desiccation and/or dropping.
Lotte Caarls, Niccolò Bassetti, Patrick Verbaarschot, Roland Mumm, Joop J. A. van Loon, M. Eric Schranz, Nina E. Fatouros   +6 more
doaj   +1 more source

giffordlabcvr/Flavivirus-GLUE: Flavivirus-GLUE version 1.0.0

, 2022
Initial release of Flavivirus ...
Robert J. Gifford
core   +1 more source

Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues

Chemical Science, 2015
The inhibitory effect of benzamidine as blocker on the protease activity of trypsin is enhanced by covalent conjugation with bioadhesive molecular glue.
Mogaki, Rina, Okuro, Kou, Aida, Takuzo
openaire   +3 more sources

Equifinality of formal (DREAM) and informal (GLUE) Bayesian approaches in hydrologic modeling? [PDF]

, 2009
In recent years, a strong debate has emerged in the hydrologic literature regarding what constitutes an appropriate framework for uncertainty estimation.
Braak, C.J.F., ter, Robinson, B.A., Gupta, H.V., Vrugt, J.A.   +3 more
core   +1 more source

From ears to experience: insights into living with long-term Glue Ear [PDF]

, 2014
Glue Ear is a common childhood condition which causes intermittent hearing loss. It is highly prevalent in children under 7 years, but is rarely discussed in teacher training. It is well understood in a medical rather than an educational context. Most of
Capewell, Carmel
core   +2 more sources