Results 11 to 20 of about 3,265,759 (283)
Targeting active RAS with molecular glue
Pharmaceutical Science AdvancesActivating mutations in RAS genes, notably KRASG12C, are pervasive in numerous cancers, presenting formidable challenges to therapy due to their elusive druggability.
Wenjing Su, Xuben Hou
doaj +3 more sources
Rational Chemical Design of Molecular Glue Degraders [PDF]
, 2023 Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic modality for eliminating classically undruggable disease-causing proteins through proteasome-mediated degradation.
Dustin Dovala (5398325) +17 more
core +7 more sources
The Rise of Molecular Glues [PDF]
Cell, 2021 2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.
openaire +2 more sources
, 2023 <p><!-- Release notes generated using configuration in .github/release.yml at main --></p> <h2>What's Changed</h2> <h3>New Features</h3> <ul> <li>Support dynamic components by @jfoster17 in https ...
Chris Beaumont +29 more
core +2 more sources
Supersaturation with water explains the unusual adhesion of aggregate glue in the webs of the moth-specialist spider, Cyrtarachne akirai [PDF]
Royal Society Open Science, 2018 Orb webs produced by araneoid spiders depend upon aggregate glue-coated capture threads to retain their prey. Moths are challenging prey for most spiders because their scales detach and contaminate the glue droplets, significantly decreasing adhesion ...
Candido Diaz +6 more
doaj +1 more source
, 2023 What's Changed Other Changes Use new location for pandas.testing by @jfoster17 in https://github.com/glue-viz/glue/pull/2381 Only force reference data change if message indicates that numerical values of data have changed by @astrofrog in https://github.
Chris Beaumont +29 more
core +1 more source
, 2023 What's Changed New Features Relax longitude range in fullsphere projections by @Carifio24 in https://github.com/glue-viz/glue/pull/2348 ### Bug Fixes Update polar log transform test values to correct matplotlib 3.7 representation by @Carifio24 in https:/
Chris Beaumont +29 more
core +1 more source
, 2023 What's Changed Bug Fixes Fixed a bug in the plugin iteration on Python 3.8 and 3.9 by @neutrinoceros in https://github.com/glue-viz/glue/pull/2377 Avoid interference of ROI patches with legend auto-placement by @dhomeier in https://github.com/glue-viz ...
Chris Beaumont +29 more
core +1 more source