Results 71 to 80 of about 3,947,894 (203)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Hydrogen mobility roll-up site selection using intuitionistic fuzzy sets based WASPAS, COPRAS and EDAS

, 2019
In this study, an intuitionistic fuzzy set based multi-criteria decision making (MCDM) method, including WASPAS, COPRAS and EDAS is proposed for selecting the best location for hydrogen mobility roll-up site selection in Romania.
Akyurt, Ibrahim Zeki, Iordache, Mihaela, Deveci, Muhammet, Bilgili, Kursad, Iordache, Ioan, Schitea, Dorin   +5 more
core   +1 more source

Molecular hydrogen supplementation in mice ameliorates lipopolysaccharide‐induced loss of interest

PCN Reports
Aim The objective of this study was to evaluate the potential of hydrogen in preventing and treating psychiatric symptoms, particularly depressed mood and loss of interest, and to explore its underlying mechanisms.
Minori Koga, Mayumi Sato, Ryuichi Nakagawa, Shinichi Tokuno, Fumiho Asai, Yuri Maezawa, Masanori Nagamine, Aihide Yoshino, Hiroyuki Toda   +8 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Frontiers in Pharmacology, 2019
Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders.
Di Wen, Rongji Hui, Jian Wang, Xi Shen, Bing Xie, Miao Gong, Feng Yu, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Estudo teórico sobre o efeito de substituintes na estrutura eletrônica de supermoléculas com múltiplas ligações de hidrogênio intermoleculares [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013Sistemas que se conectam através de múltiplas ligações de hidrogênio são a pedra angular ...
Lopez, Alfredo Henrique Duarte
core  

Contribution to modeling hydrogen permeation and barrier layer optimization in blow molded plastic liners for an on-board compressed hydrogen tanks

, 2022
Blow Molded Plastic Liners (BMPL) for on-board type IV Compressed Gaseous Hydrogen (CGH2) storage tanks consist of a high-molecular-weight polymer wall that serves as a permeation layer for hydrogen gas.
Bournival, Sylvain, Benrabah, Zohir, Bardetti, Anna, Ilinca, Florin   +3 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Cutting-edge advances in hydrogen applications for the medical and pharmaceutical industries [PDF]

This article is part of a special issue entitled: ICEESEN-2024 (Akansu) published in International Journal of Hydrogen Energy.The adoption of clean hydrogen is expected to transform the global energy landscape, reducing greenhouse gas emissions, bridging
Alhajeri, A, Ghazal, H, Kodresko, A, Jouhara, H, Olabi, V   +4 more
core   +1 more source