Results 111 to 120 of about 7,162,052 (308)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Morphological and molecular analyses demonstrate identification problems of Anopheles nuneztovari (Diptera: Culicidae) using dichotomous keys

, 2010
RESUMEN : El Grupo Oswaldoi, subgénero Nyssorhynchus (Diptera: Culicidae), incluye 16 especies. Algunas de estas especies presentan una alta variabilidad morfológica intraespecífica y similitud interespecie; lo anterior puede ocasionar dificultad en la ...
Gómez García, Giovan Fernando, Cienfuegos Gallet, Astrid Vanessa, Gutiérrez Builes, Lina Andrea, Correa Ochoa, Margarita María, Conn, Jan E.   +4 more
core   +1 more source

Newsletter Institute of Medical Molecular Biotechnology Issue 14 Disember 2021 / Institute of Medical Molecular Biotechnology [PDF]

, 2021
The Institute of Medical Molecular Biotechnology (IMMB) at Universiti Teknologi MARA (UiTM) launched its inaugural newsletter in November 2020. This publication serves as a platform to disseminate the institute's latest research activities, events, and ...
Universiti Teknologi MARA, Institute of Medical Molecular Biotechnology
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Site-selective α-C(sp3)–H arylation of dialkylamines via hydrogen atom transfer catalysis-enabled radical aryl migration

Nature Communications
Site-selective C(sp3)–H arylation is an appealing strategy to synthesize complex arene structures but remains a challenge facing synthetic chemists. Here we report the use of photoredox-mediated hydrogen atom transfer (HAT) catalysis to accomplish the ...
Jie Xu, Ruihan Li, Yijian Ma, Jie Zhu, Chengshuo Shen, Heng Jiang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Growing Molecular Plant Sciences

, 2014
The VT Molecular Plant Sciences Magazine features the work of scientists and students in the department who use molecular approaches to unravel the mysteries of ...
Molecular Plant Sciences, Fralin Life Sciences Institute   +1 more
core  

Seed dormancy and seed longevity: from genetic variation to gene identification [PDF]

, 2014
Seed dormancy and seed longevity are the most important survival traits in the soil seed bank. Both traits are induced during seed maturation and evolved to assure seed survival during environmental conditions that cannot support the regular course of ...
Nguyen, T.P., Molecular Plant Physiology, Sub Molecular Plant Physiology   +2 more
core  

The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice

Scientific Reports
Modern life’s fast-paced and the unexpected conditions contribute to escalating stress levels, often leading to anxiety disorders and posing significant challenges to physical and mental health. In judicial practice, the parties often suffer from anxiety
Xiaorui Su, Xuetong Dong, Chao-Long Lu, Minglong Zhang, Yaping Li, Han Xiao, Jian Wang, Yufei Sun, Bin Cong, Songjun Wang   +9 more
doaj   +1 more source