Results 131 to 140 of about 1,608,476 (265)

A framework for the molecular identification of CHIP for clinical research. [PDF]

HGG Adv
Harraka P, O'Reilly RL, Burke J, Yeh P, Howlett K, Behrouzfar K, Belluoccio D, Rewse A, Lynch BM, Bubb KJ, Nicholls SJ, Milne RL, Southey MC.   +12 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Molecular identification of <i>Escherichia coli</i> in poultry wet markets in Sulaymaniyah Province, Iraq. [PDF]

Open Vet J
Rashid AM, Khidhir ZK, Arif ED.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Isolation and Molecular Identification of Potentially Pathogenic Free-Living Amoeba in Tap Water Faucets in Quezon City, Philippines. [PDF]

J Parasitol Res
Tiglao JER, Adao DEV.
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Microbial Contamination and Molecular Identification of Predominant Bacteria in Fermented Milk Products in Mbarara, Uganda. [PDF]

Cureus
Kamwine M, Nalumaga PP, Wasswa FB, Naume Joyce K, Musau IA, Boum Ii Y, Bazira J.   +6 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Molecular Identification of the Viruses Associated with Sweetpotato Diseases in Côte d'Ivoire. [PDF]

Viruses
Tapily EHH, Pita JS, Amoakon WJ, Eni A, Kouassi KM, Kouassi NK, Tiendrébéogo F.   +6 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source