Results 151 to 160 of about 1,608,476 (265)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Molecular identification of hookworm infection in humans, dogs and cats in Lao People's Democratic Republic. [PDF]

Infect Dis Poverty
Sayasone S, Norkhankham C, Many S, Homsana A, Inpankaew T, Odermatt P.   +5 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Candiduria in catheterized ICU patients: epidemiology, molecular identification, and antifungal susceptibility. [PDF]

Iran J Microbiol
Ahmadi A, Hazrati E, Noorifard M, Farahnejad Z, Mohammadimehr M.   +4 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Morphological and molecular identification of Fusarium wilt resistance in tomato cultivars mediated by defense gene response. [PDF]

Sci Rep
Khan A, Rasool G, Ullah A, Waris M, Ahmed K.   +4 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Molecular Identification of <i>Schistosoma</i> Species Associated with Atypical Urinary Eggs in Abuja (Nigeria): Evidence of Potential Zoonotic Transmission. [PDF]

Trop Med Infect Dis
Jacob SM, Akinbo SY, Ajakaye OG, Ekpo UF, Omoruyi Z, Agbana T, Makau-Barasa L, Aderogba MO, Diehl JC, Bell D, Bayegun AA, Okungbowa MA, A-Enegela J, Akinbo FO.   +13 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Molecular Identification and Phenotypic Antimicrobial Resistance of <i>Acinetobacter</i> spp. from an Equine University Clinic in Germany. [PDF]

Antibiotics (Basel)
Stöckle SD, Sauerwein A, Mueller E, Gehlen H.   +3 more
europepmc   +1 more source