Results 121 to 130 of about 1,769,037 (315)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Correction: Yu et al. The Role of circTmeff-1 in Morphine Addiction Memory of Mice. Cells 2023, 12, 1985

Cells
In the original publication [...]
Hailei Yu, Boyang Wen, Yun Lu, Bing Xie, Feng Yu, Minglong Zhang, Chunling Ma, Bin Cong, Di Wen, Haitao Bi   +9 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Protein identification and tracking in two-dimensional electrophoretic gels by minimal protein identifiers.

, 2004
Protein identification by matrix-assisted laser desorption/ionization mass-spectrometry peptide mass fingerprinting (MALDI-MS PMF) represents a cornerstone of proteomics. However, it often fails to identify low-molecular-mass proteins, protein fragments,
Jens Mattow, Schmidt, Frank, Kaufmann, Stefan H. E., Hoehenwarter, Wolfgang, Frank Schmidt, Mattow, Jens, Kaufmann, Stefan HE, Ulrich E. Schaible, Frank Siejak, Schaible, Ulrich E, Wolfgang Höhenwarter, Höhenwarter, Wolfgang, Schaible, Ulrich E., Siejak, Frank, Stefan H.E. Kaufmann   +14 more
core   +1 more source

Integrated transcriptomics and metabolomics confirms the oxidative stress mechanism of hypothermia-induced neuronal necroptosis

Cellular & Molecular Biology Letters
Abnormal climate change seriously endangers the safety of outdoor work and life, often causing hypothermia-induced coma or death. As the underlying mechanism has not been fully elucidated, a targeted treatment for hypothermia-triggered neuronal injury ...
Song-Jun Wang, Chao-Long Lu, Fu Zhang, Xue-Tong Dong, Xiao-Rui Su, Jing-Jing Sha, Bin Cong, Xia Liu   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Identification of Rays through DNA Barcoding: An Application for Ecologists

, 2012
DNA barcoding potentially offers scientists who are not expert taxonomists a powerful tool to support the accuracy of field studies involving taxa that are diverse and difficult to identify.
Owen O'Shea, Austin Chris M., Florencia Cerutti-Pereyra (158763), Mark G. Meekan (111192), Nu-Wei V. Wei (158766), Meekan, M., Bradshaw, C.J.A., Pereyra, Florencia Cerutti, Bradshaw, Corey J A, Meekan, Mark, Bradshaw, Corey, Bradshaw, C., Wei Nu-Wei V., Chris M Austin, O'Shea, O., Austin, Christopher, O'Shea Owen, Nu-Wei V Wei, Pereyra, Florencia, Shea, Owen, Shea, Owen O', Chris M. Austin (158773), Bradshaw Corey J. A., Wei, Nu, Wei, N-W.V., Wei, Nu Wei V, Florencia Cerutti-Pereyra, Cerutti-Pereyra, F., Austin, C., Cerutti-Pereyra Florencia, Owen O'Shea (158769), Meekan, Mark G, Corey J. A. Bradshaw (158770), Meekan Mark G., Mark G Meekan, Austin, C.M., Wei, N., Corey J A Bradshaw, Meekan, M.G., Austin, Christopher M   +39 more
core   +1 more source

CCK2R regulates METH-induced CPP acquisition within VTA-BLA-BNST circuit in male mice

Translational Psychiatry
Methamphetamine (METH) addiction is a severe public health issue driven by maladaptive neuroplasticity in reward circuits. Cholecystokinin (CCK), a neuropeptide abundant in the ventral tegmental area (VTA), modulates addiction-related behaviors through ...
Jian Wang, Minglong Zhang, Linyi Qiao, Yeneng Pu, Yufei Sun, Xiaorui Su, Rongji Hui, Ludi Zhang, Bing Xie, Bin Cong, Yixiao Luo, Chunling Ma, Di Wen   +12 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Fruiting Body Formation in Basidiomycetes

, 2016
Establishment of the dikaryotic mycelium and formation of fruiting bodies are highly complex developmental programmes that are activated by a combination of environmental cues.
Lugones, L.G., Sub Molecular Microbiology, Wosten, H.A.B., Pelkmans, J.F., Dep Biologie, Molecular Microbiology   +5 more
core   +1 more source