Results 241 to 250 of about 3,004,160 (310)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Molecular Identification and Characterization of a Novel Gammaherpesvirus in Wild Rabbits. [PDF]

Viruses
Abade Dos Santos FA, Duarte A, Varandas IC, Barros SS, Henriques AM, Fagulha T, Duarte MD.   +6 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Correction: Molecular identification, antibiotic susceptibility, and biofilm formation of airborne bacteria. [PDF]

AMB Express
Hussain MA, Zafar M, Khan YS, Said KB, Anwar S, Saeed M, Abdulhakeem MA, Snoussi M, Kausar MA.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Molecular identification of <i>Brucella abortus</i> in secondary hosts of goats and sheep in Magelang, Central Java, Indonesia. [PDF]

Open Vet J
Ardiyanto D, Wuryastuty H, Yanuartono Y, Sarmin S, Wasito R, Airin CM, Widiati DT, Mubarokah WW.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Assessment of the molecular identification algorithm and its impact on antifungal susceptibilities against clinical <i>Fusarium</i> isolates: a multicentre study in Taiwan, 2011-2023. [PDF]

JAC Antimicrob Resist
Chen PY, Wu CJ, Wu UI, Liu WD, Chen YC.
europepmc   +1 more source

Sarcocystis species: molecular identification and seroprevalence in water buffaloes (Bubalus bubalis). [PDF]

BMC Vet Res
Toaleb NI, Shaapan RM, Elaadli H, Abdel Megeed KN, Aboelsoued D.   +4 more
europepmc   +1 more source

First Report of <i>Cystobasidium slooffiae</i> in Human Wounds from China: Molecular Identification and Clinical Insights. [PDF]

Infect Drug Resist
Huang J, Guo L, Zhang G, Tsui CKM, Huang W, Li K, Jin X, Liu Y, Chen X, Tang C, Xu Y, Lin N.   +11 more
europepmc   +1 more source