Results 1 to 10 of about 4,230,488 (185)
RPA shields inherited DNA lesions for post-mitotic DNA synthesis
Nature Communications, 2021 Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell ...
Aleksandra Lezaja +5 more
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Nature Communications, 2023 The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of ...
Nina Schmolka +9 more
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Current Pharmaceutical Design, 2014 Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects.
Vanommeslaeghe, Kenno +2 more
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Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains
Nature Communications, 2022 Mapping nucleolar-associated domains (NADs) is challenging as the nucleolus is membrane-less. Here the authors adapted the DNA adenine methyltransferase identification (DamID) method by engineering a “nucleolar histone” that can mark genomic contacts ...
Cristiana Bersaglieri +6 more
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Cell Discovery, 2021 Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself.
Flurina Boehi +2 more
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Cell Death and Disease, 2022 Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera +18 more
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HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides
Nature Communications, 2022 HAESA and HSL2 are receptors for IDA/IDL-family signaling peptides in plants. Here the authors show that HSL1, previously shown to recognize CLE9, preferentially binds IDA/IDL peptides and regulates leaf epidermal patterning independently of CLE peptides.
Andra-Octavia Roman +5 more
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Biology, 2021 Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1, Vav2, Vav3) that work downstream of
Sonia Rodríguez-Fdez +6 more
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Cancer Cell International, 2023 Background Cancer-secreted exovesicles are important for cell-to-cell communication by altering cancer-related signalling pathways. Exovesicles-derived miRNAs (exomiRNAs)-target genes can be useful for diagnostic and prognostic purposes. Methods ExomiRNA
Antonio Altuna-Coy +4 more
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Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Life Science Alliance, 2021 This study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.
Jone Michelena +3 more
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