Results 1 to 10 of about 14,308,960 (385)
Nature Communications, 2023 The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of ...
Nina Schmolka +9 more
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Immunosenescence: molecular mechanisms and diseases
Signal Transduction and Targeted Therapy, 2023 Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence).
Zaoqu Liu +9 more
semanticscholar +1 more source
RPA shields inherited DNA lesions for post-mitotic DNA synthesis
Nature Communications, 2021 Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell ...
Aleksandra Lezaja +5 more
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Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Signal Transduction and Targeted Therapy, 2023 Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes.
Yiwen Li +7 more
semanticscholar +1 more source
Molecular mechanisms of tumor resistance to radiotherapy
Molecular Cancer, 2023 Background Cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma.
Yuehua Wu +3 more
semanticscholar +1 more source
Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains
Nature Communications, 2022 Mapping nucleolar-associated domains (NADs) is challenging as the nucleolus is membrane-less. Here the authors adapted the DNA adenine methyltransferase identification (DamID) method by engineering a “nucleolar histone” that can mark genomic contacts ...
Cristiana Bersaglieri +6 more
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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Signal Transduction and Targeted Therapy, 2023 Having a hypoxic microenvironment is a common and salient feature of most solid tumors. Hypoxia has a profound effect on the biological behavior and malignant phenotype of cancer cells, mediates the effects of cancer chemotherapy, radiotherapy, and ...
Zhou Chen +4 more
semanticscholar +1 more source
Cell Discovery, 2021 Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself.
Flurina Boehi +2 more
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Molecular Mechanisms of High-Altitude Acclimatization
International Journal of Molecular Sciences, 2023 High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric hypoxia and curtail the development of HAIs.
R. Mallet +6 more
semanticscholar +1 more source
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
semanticscholar +1 more source