Results 11 to 20 of about 4,230,607 (304)

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure

Nature Communications, 2022
While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente, Alexei Novoloaca, Vincent Cahais, Zainab Awada, Cyrille Cuenin, Natália Spitz, André Lopes Carvalho, Adriane Feijó Evangelista, Camila Souza Crovador, Rui Manuel Reis, Zdenko Herceg, Vinicius de Lima Vazquez, Akram Ghantous   +12 more
doaj   +1 more source

Plant responses to photoperiod [PDF]

, 2009
Photoperiod controls many developmental responses in animals, plants and even fungi. The response to photoperiod has evolved because daylength is a reliable indicator of the time of year, enabling developmental events to be scheduled to coincide with ...
Abe, Achard, Adams, Adams, Alabadi, An, Asai, Aukerman, Balasubramanian, Banerjee, Batutis, Beales, Ben-Naim, Berardini, Bernier, Blazquez, Blázquez, Blázquez, Bollman, Bongard-Pierce, Borchert, Bouveret, Bäurle, Böhlenius, Cerdán, Chae, Chailkhyan, Chen, Chen, Chien, Chincinska, Clarke, Cockcroft, Corbesier, David, Devlin, Doi, Dudley, Duncan, Fahlgren, Farré, Foster, Fowler, Gandikota, Gardner, Giavalisco, Goldman, Gonthier, Grigg, Hackett, Halliday, Hayama, Hayama, Haywood, He, He, Henderson, Heyer, Holm, Hotta, Hsu, Hunter, Hunter, Imaizumi, Imaizumi, Izawa, Jackson, Jackson, Jackson, Jackson, Jaeger, Jang, Jung, Kanrar, Kelly, Kim, Kim, Kim, Kim, Kojima, Komiya, Kotake, Kusnetsov, Laubinger, Lauter, Lee, Lee, Lin, Martinez-Garcia, Martínez, Mathieu, McClung, Michael, Moon, Mouradov, Más, Nilsson, Onouchi, Orkwiszewski, Osterlund, Park, Peragine, Pineiro, Poethig, Poethig, Pouteau, Razem, Reeves, Roberts, Robinson, Robson, Roden, Rodriguez-Falcon, Saijo, Samach, Sawa, Schmid, Schwarz, Searle, Seo, Singer, Sivitz, Smith, Somers, Souer, Stadler, Steward, Suàrez-López, Swiezewski, Takada, Takeno, Tamaki, Telfer, Tessadori, Thomas, Turner, Valverde, Vega, Von Arnim, Wang, Wang, Weigel, Wenkel, Wigge, Willmann, Wu, Xie, Yamaguchi, Yan, Yanovsky, Yanovsky, Yoo, Yoo, Yu, Zeevaart   +154 more
core   +1 more source

Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? [PDF]

, 2017
No abstract ...
Kennedy, Simon, Salt, Ian P.
core   +1 more source

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Nature Communications, 2018
Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study ...
Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer   +5 more
doaj   +1 more source

RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant

Scientific Reports, 2021
Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types.
Paula Rofes, Marta Pineda, Lídia Feliubadaló, Mireia Menéndez, Rafael de Cid, Carolina Gómez, Eva Montes, Gabriel Capellá, Joan Brunet, Jesús del Valle, Conxi Lázaro   +10 more
doaj   +1 more source

The molecular genetics and cellular mechanisms underlying pulmonary arterial hypertension [PDF]

, 2012
Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement.
Machado, Rajiv
core   +2 more sources

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Cell Reports, 2017
The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection.
Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer   +4 more
doaj   +1 more source

The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase

Epigenetics & Chromatin, 2023
Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Eva Monte-Serrano, Patricia Morejón-García, Ignacio Campillo-Marcos, Aurora Campos-Díaz, Elena Navarro-Carrasco, Pedro A. Lazo   +5 more
doaj   +1 more source

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source