Results 251 to 260 of about 4,230,607 (304)
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Inherited Thrombocytopenias: Molecular Mechanisms
Seminars in Thrombosis and Hemostasis, 2004Each megakaryocyte forms 10(3) platelets and 10(11) platelets are replenished daily. The unique and amazing mechanisms that allow megakaryocytes to become giant and polyploid and to release such a large number of platelets are still poorly understood.
BALDUINI CL, SAVOIA, ANNA
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Migraine: New Molecular Mechanisms
The Neuroscientist, 2005Migraine is an episodic headache disorder affecting more than 10% of the general population. Migraine arises from a primary brain dysfunction that leads to activation and sensitization of the trigeminovascular system. A major incompletely understood issue in the neurobiology of migraine concerns the molecular and cellular mechanisms that underlie the ...
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Understanding molecular structure from molecular mechanics
Journal of Computer-Aided Molecular Design, 2011Molecular mechanics gives us a well known model of molecular structure. It is less widely recognized that valence bond theory gives us structures which offer a direct interpretation of molecular mechanics formulations and parameters. The electronic effects well-known in physical organic chemistry can be directly interpreted in terms of valence bond ...
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2017
Abstract The development of the atherosclerotic plaque relies on specific cognate interactions between ligands and receptors with the ability to regulate cell recruitment, inflammatory signalling, and the production of powerful inflammatory and bioactive lipid mediators.
Claudia Monaco, Giuseppina Caligiuri
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Abstract The development of the atherosclerotic plaque relies on specific cognate interactions between ligands and receptors with the ability to regulate cell recruitment, inflammatory signalling, and the production of powerful inflammatory and bioactive lipid mediators.
Claudia Monaco, Giuseppina Caligiuri
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1991
Abstract The earliest reference known to the author on molecular mechanics is to be found in a paper by Andrews (1930), which has to do with vibrational spectroscopy. Andrews indicated that if we really understood the underlying fundamentals in this area, we should be able to calculate all of the kinds of things with which this ...
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Abstract The earliest reference known to the author on molecular mechanics is to be found in a paper by Andrews (1930), which has to do with vibrational spectroscopy. Andrews indicated that if we really understood the underlying fundamentals in this area, we should be able to calculate all of the kinds of things with which this ...
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Journal of Chemical Theory and Computation, 2006
The multiconfiguration molecular mechanics (MCMM) method is a general algorithm for generating potential energy surfaces for chemical reactions by fitting high-level electronic structure data with the help of molecular mechanical (MM) potentials.
Hai, Lin +3 more
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The multiconfiguration molecular mechanics (MCMM) method is a general algorithm for generating potential energy surfaces for chemical reactions by fitting high-level electronic structure data with the help of molecular mechanical (MM) potentials.
Hai, Lin +3 more
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1995
This chapter examines molecular mechanics. By bringing together features from both the Central Force Field and Valence Force Field methods, it proved possible to derive energy functions which were at once chemically intuitive while still retaining the concept of through space attractions and repulsions.
H. Grant Guy, Richards W. Graham
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This chapter examines molecular mechanics. By bringing together features from both the Central Force Field and Valence Force Field methods, it proved possible to derive energy functions which were at once chemically intuitive while still retaining the concept of through space attractions and repulsions.
H. Grant Guy, Richards W. Graham
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Molecular mechanisms of pathogenesis
Clinics in Dermatology, 1983Abstract The first clue to the etiology of pemphigus was established in 1964, when Beutner and Jordon 1 demonstrated that serum from pemphigus patients contained autoantibodies that bound to an intercellular substance (ICS) of skin and mucosa. Subsequently, skin biopsies revealed in vivo deposition of auto-antibodies in the epidermis of pemphigus ...
K H, Singer, G S, Lazarus
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Molecular mechanisms of immunosuppression
Journal of Autoimmunity, 1992The immunosuppressive drug cyclosporin A (CsA, Sandimmun, SIM) is currently being evaluated in a variety of autoimmune disorders with some remarkable successes. Despite the wide empiric application of CsA, the precise mechanism of action of this drug remains elusive.
G, Baumann +6 more
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Molecular mechanisms of photocarcinogenesis
Frontiers in Bioscience, 2002Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto ...
Yasuhiro, Matsumura +1 more
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