Results 21 to 30 of about 4,230,607 (304)

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

Nature Communications, 2022
S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and ...
Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov   +30 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Molecular mechanisms of etoposide

EXCLI journal, 2015
EXCLI Journal ; Vol.
Montecucco A, Zanetta F, Biamonti G
openaire   +3 more sources

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
core   +2 more sources

Mechanisms of two-color laser-induced field-free molecular orientation [PDF]

, 2012
Two mechanisms of two-color (\omega + 2\omega) laser-induced field-free molecular orientation, based on the hyperpolarizability and ionization depletion, are explored and compared. The CO molecule is used as a computational example.
Eugene Frumker, K. A. Peterson, L. D. Landau, L. V. Keldysh, L. V. Keldysh, Michael Spanner, Paul Corkum, Serguei Patchkovskii, T. H. Dunning, Jr., W. H. Press   +9 more
core   +2 more sources

Author Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs

Scientific Data, 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759 ...
Egor Marin, Aleksandra Luginina, Anastasiia Gusach, Kirill Kovalev, Sergey Bukhdruker, Polina Khorn, Vitaly Polovinkin, Elizaveta Lyapina, Andrey Rogachev, Valentin Gordeliy, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy   +12 more
doaj   +1 more source

NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps [PDF]

, 2013
Molecular biology knowledge can be systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist a number of maps of molecular interactions containing detailed description of various cell mechanisms.
Barillot, Emmanuel, Calzone, Laurence, Cohen, David, Kuperstein, Inna, Pook, Stuart, Viara, Eric, Zinovyev, Andrei   +6 more
core   +5 more sources

Mirror proteorhodopsins

Communications Chemistry, 2023
Proteorhodopsins (PRs), bacterial light-driven outward proton pumps comprise the first discovered and largest family of rhodopsins, they play a significant role in life on the Earth.
Ivan S. Okhrimenko, Kirill Kovalev, Lada E. Petrovskaya, Nikolay S. Ilyinsky, Alexey A. Alekseev, Egor Marin, Tatyana I. Rokitskaya, Yuri N. Antonenko, Sergey A. Siletsky, Petr A. Popov, Yuliya A. Zagryadskaya, Dmytro V. Soloviov, Igor V. Chizhov, Dmitrii V. Zabelskii, Yury L. Ryzhykau, Alexey V. Vlasov, Alexander I. Kuklin, Andrey O. Bogorodskiy, Anatolii E. Mikhailov, Daniil V. Sidorov, Siarhei Bukhalovich, Fedor Tsybrov, Sergey Bukhdruker, Anastasiia D. Vlasova, Valentin I. Borshchevskiy, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Ernst Bamberg, Valentin I. Gordeliy   +28 more
doaj   +1 more source

Molecular mechanisms of neural crest formation [PDF]

, 1999
The neural crest is a transient population of multipotent precursor cells named for its site of origin at the crest of the closing neural folds in vertebrate embryos.
Bronner-Fraser, Marianne, LaBonne, Carole   +1 more
core   +1 more source

A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity

Emerging Microbes and Infections, 2021
African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses.
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan   +19 more
doaj   +1 more source