Results 21 to 30 of about 14,308,960 (385)
Biology, 2021 Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1, Vav2, Vav3) that work downstream of
Sonia Rodríguez-Fdez +6 more
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Signal Transduction and Targeted Therapy, 2022 Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases,
Jun Guo +6 more
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Molecular mechanisms of lidocaine
Annals of Medicine & Surgery, 2021 Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can ...
Resiana Karnina +3 more
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Molecular mechanisms and physiological functions of mitophagy
EMBO Journal, 2021 Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control.
Mashun Onishi +4 more
semanticscholar +1 more source
Molecular mechanisms of synaptogenesis
Frontiers in Synaptic Neuroscience, 2022 Synapses are the basic units for information processing and storage in the nervous system. It is only when the synaptic connection is established, that it becomes meaningful to discuss the structure and function of a circuit. In humans, our unparalleled cognitive abilities are correlated with an increase in the number of synapses.
Cai Qi +4 more
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Molecular Mechanisms of Drug Resistance in Staphylococcus aureus
International Journal of Molecular Sciences, 2022 This paper discusses the mechanisms of S. aureus drug resistance including: (1) introduction. (2) resistance to beta-lactam antibiotics, with particular emphasis on the mec genes found in the Staphylococcaceae family, the structure and occurrence of ...
B. Młynarczyk-bonikowska +3 more
semanticscholar +1 more source
Nature Communications, 2022 While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente +12 more
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Cell Death and Differentiation, 2018 Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
L. Galluzzi +168 more
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Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives [PDF]
, 2020 Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric ...
Berwian +11 more
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Molecular mechanisms of neural crest formation [PDF]
, 1999 The neural crest is a transient population of multipotent precursor cells named for its site of origin at the crest of the closing neural folds in vertebrate embryos.
Bronner-Fraser, Marianne +1 more
core +1 more source