Results 31 to 40 of about 4,304,368 (356)

The molecular genetics and cellular mechanisms underlying pulmonary arterial hypertension [PDF]

, 2012
Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement.
Machado, Rajiv
core   +2 more sources

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

Journal of Experimental & Clinical Cancer Research, 2019
Background Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays a critical role in thyroid tumors.
Mara Mazzoni, Giuseppe Mauro, Marco Erreni, Paola Romeo, Emanuela Minna, Maria Grazia Vizioli, Cristina Belgiovine, Maria Grazia Rizzetti, Sonia Pagliardini, Roberta Avigni, Maria Chiara Anania, Paola Allavena, Maria Grazia Borrello, Angela Greco   +13 more
doaj   +1 more source

Abstract P-5: Modern Membrane Mimetic Systems for Cryo-EM Based Structural Analysis [PDF]

International Journal of Biomedicine, 2019
Background: Single particle approach that is used to image the sample by an electron beam requires receptors to be extracted from the cell membrane and placed into the sample grid in the solubilized form.
Egor S. Kolesnikov, Polina A. Khorn, Anastasiia U. Gusach, Aleksandra P. Luginina, Alexey V. Mishin   +4 more
doaj   +1 more source

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Cells, 2021
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina, Michael B. Evgen’ev, David G. Garbuz   +2 more
doaj   +1 more source

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

Cells, 2019
Colorectal cancer (CRC), the second most common cause of cancer mortality in the Western world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells ...
Pit Ullmann, Martin Nurmik, Rubens Begaj, Serge Haan, Elisabeth Letellier   +4 more
doaj   +1 more source

Transcriptomic landscape of TIMP3 oncosuppressor activity in thyroid carcinoma

Cancer Cell International, 2022
Background Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in several tumor types.
M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri, A. Greco   +8 more
doaj   +1 more source

Mechanisms of decoherence in weakly anisotropic molecular magnets

, 2000
Decoherence mechanisms in crystals of weakly anisotropic magnetic molecules, such as V15, are studied. We show that an important decohering factor is the rapid thermal fluctuation of dipolar interactions between magnetic molecules. A model is proposed to
A. Abragam, A. Abragam, A. Fort, B. E. Kane, B. N. Harmon, D. Garanin, D. Gatteschi, D. Gatteschi, D. Gatteschi, F. Luis, J. R. Friedman, L. S. Schulman, L. Thomas, M. I. Katsnelson, N. V. Prokof'ev, N. V. Prokof'ev, O. Kahn, P. W. Shor, V. V. Dobrovitski   +18 more
core   +1 more source

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source

The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility

Cells, 2022
Meiosis is a highly conserved specialized cell division process that generates haploid gametes. Many of its events are associated with dynamically regulated chromosomal structures and chromatin remodeling, which are mainly modulated by histone ...
Fernando Sánchez-Sáez, Raquel Sainz-Urruela, Natalia Felipe-Medina, Yazmine B. Condezo, Manuel Sánchez-Martín, Elena Llano, Alberto M. Pendás   +6 more
doaj   +1 more source

Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone [PDF]

, 2019
In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discrimination ...
Biagioni, Stefano, Cacci, Emanuele, Gioia, Roberta, Lupo, Giuseppe, Nisi, PAOLA SERENA   +4 more
core   +1 more source