Results 31 to 40 of about 14,308,960 (385)
RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant
Scientific Reports, 2021 Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types.
Paula Rofes +10 more
doaj +1 more source
Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]
, 2005 Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim +3 more
core +2 more sources
Epigenetics & Chromatin, 2023 Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Eva Monte-Serrano +5 more
doaj +1 more source
Molecular mechanisms of cell death in neurological diseases
Cell Death and Differentiation, 2021 Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS. Abnormalities in PCD signalling cascades,
Diane Moujalled +2 more
semanticscholar +1 more source
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Nature Communications, 2022 S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and ...
Elizaveta Lyapina +30 more
doaj +1 more source
Molecular Mechanisms of Atopic Dermatitis Pathogenesis
International Journal of Molecular Sciences, 2021 Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process ...
Jowita Sroka-Tomaszewska, M. Trzeciak
semanticscholar +1 more source
, 2017 Ectoine, a compatible solute and osmolyte, is known to be an effective protectant of biomolecules and whole cells against heating, freezing and extreme salinity.
Hahn, Marc Benjamin +5 more
core +1 more source
Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports, 2017 The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection.
Stefania Pellegrino +4 more
doaj +1 more source
A molecular mechanism for transthyretin amyloidogenesis [PDF]
Nature Communications, 2019 AbstractHuman transthyretin (TTR) is implicated in several fatal forms of amyloidosis. Many mutations of TTR have been identified; most of these are pathogenic, but some offer protective effects. The molecular basis underlying the vastly different fibrillation behaviours of these TTR mutants is poorly understood.
Michael Haertlein +14 more
openaire +11 more sources
Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? [PDF]
, 2017 No abstract ...
Kennedy, Simon, Salt, Ian P.
core +1 more source