Results 31 to 40 of about 4,230,607 (304)

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

Journal of Experimental & Clinical Cancer Research, 2019
Background Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays a critical role in thyroid tumors.
Mara Mazzoni, Giuseppe Mauro, Marco Erreni, Paola Romeo, Emanuela Minna, Maria Grazia Vizioli, Cristina Belgiovine, Maria Grazia Rizzetti, Sonia Pagliardini, Roberta Avigni, Maria Chiara Anania, Paola Allavena, Maria Grazia Borrello, Angela Greco   +13 more
doaj   +1 more source

Molecular model of a sensor of two-component signaling system

Scientific Reports, 2021
Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator.
Yury L. Ryzhykau, Philipp S. Orekhov, Maksim I. Rulev, Alexey V. Vlasov, Igor A. Melnikov, Dmytro A. Volkov, Mikhail Yu. Nikolaev, Dmitrii V. Zabelskii, Tatiana N. Murugova, Vladimir V. Chupin, Andrey V. Rogachev, Andrey Yu. Gruzinov, Dmitri I. Svergun, Martha E. Brennich, Ivan Yu. Gushchin, Montserrat Soler-Lopez, Arne Bothe, Georg Büldt, Gordon Leonard, Martin Engelhard, Alexander I. Kuklin, Valentin I. Gordeliy   +21 more
doaj   +1 more source

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Cells, 2021
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina, Michael B. Evgen’ev, David G. Garbuz   +2 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

Cells, 2019
Colorectal cancer (CRC), the second most common cause of cancer mortality in the Western world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells ...
Pit Ullmann, Martin Nurmik, Rubens Begaj, Serge Haan, Elisabeth Letellier   +4 more
doaj   +1 more source

Transcriptomic landscape of TIMP3 oncosuppressor activity in thyroid carcinoma

Cancer Cell International, 2022
Background Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in several tumor types.
M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri, A. Greco   +8 more
doaj   +1 more source

Mechanisms of decoherence in weakly anisotropic molecular magnets

, 2000
Decoherence mechanisms in crystals of weakly anisotropic magnetic molecules, such as V15, are studied. We show that an important decohering factor is the rapid thermal fluctuation of dipolar interactions between magnetic molecules. A model is proposed to
A. Abragam, A. Abragam, A. Fort, B. E. Kane, B. N. Harmon, D. Garanin, D. Gatteschi, D. Gatteschi, D. Gatteschi, F. Luis, J. R. Friedman, L. S. Schulman, L. Thomas, M. I. Katsnelson, N. V. Prokof'ev, N. V. Prokof'ev, O. Kahn, P. W. Shor, V. V. Dobrovitski   +18 more
core   +1 more source

Impact of receiver reaction mechanisms on the performance of molecular communication networks [PDF]

, 2013
In a molecular communication network, transmitters and receivers communicate by using signalling molecules. At the receivers, the signalling molecules react, via a chain of chemical reactions, to produce output molecules.
Chou, Chun Tung
core   +1 more source

From lab to field : yield stability and shade avoidance genes are massively differentially expressed in the field [PDF]

, 2020
To unravel molecular mechanisms with the ultimate goal to achieve improved stress resilience or increased yield, plants are often studied under highly controlled conditions in which stresses are applied and in which growth‐ or architecture‐related traits
De Block, Jolien, De Vliegher, Alex, Demuynck, Kirin, Inzé, Dirk, Nelissen, Hilde, Sprenger, Heike, Van Hautegem, Tom   +6 more
core   +2 more sources

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source