Results 51 to 60 of about 4,304,368 (356)

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Cell Reports
Summary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation ...
Antonio Galarreta, Virginia Pasti, Julia Vornberger, Ralph Imhof, Mariano Oppikofer, Matthias Altmeyer   +5 more
doaj   +1 more source

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Nature Communications, 2016
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides ...
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga   +11 more
doaj   +1 more source

Regulation of Glucose Metabolism by NAD⁺ and ADP-Ribosylation

Cells, 2019
Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell
Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger   +2 more
doaj   +1 more source

Mechanically interlocked molecular handcuffs

Chemical Science, 2022
Mechanically interlocked molecules that employ a handcuff component provide a pathway to highly unusual structures, a new nomenclature is proposed which helps to identify opportunities for employing this structural unit for new architectures.
Nicholas Pearce, Marysia Tarnowska, Nathan J. Andersen, Alexander Wahrhaftig-Lewis, Ben S. Pilgrim, Neil R. Champness   +5 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model

Molecular Oncology, 2022
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC).
Javier Robles‐Valero, Lucía Fernández‐Nevado, Myriam Cuadrado, Luis Francisco Lorenzo‐Martín, Isabel Fernández‐Pisonero, Antonio Abad, Esther Redín, Luis Montuenga, Dionisio Martín‐Zanca, Anna Bigas, Moisés Mallo, Mercedes Dosil, Xosé R. Bustelo   +12 more
doaj   +1 more source

Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight

Cells, 2021
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source