Results 61 to 70 of about 4,304,368 (356)

The epigenetic circle: feedback loops in the maintenance of cellular memory

Epigenetics & Chromatin
The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses.
Marko Tomljanović, Cita Hanif Muflihah, Dejan Rajkovski, Pawel Mikulski   +3 more
doaj   +1 more source

TUBB4B Downregulation Is Critical for Increasing Migration of Metastatic Colon Cancer Cells

Cells, 2019
Tumor metastasis, the major problem for clinical oncology in colon cancer treatment, is linked with an epithelial-mesenchymal transition (EMT). The observed cellular transformation in this process is manifested by cell elongation, enhanced cell migration
Katarzyna Sobierajska, Wojciech M. Ciszewski, Marta E. Wawro, Katarzyna Wieczorek-Szukała, Joanna Boncela, Izabela Papiewska-Pajak, Jolanta Niewiarowska, M. Anna Kowalska   +7 more
doaj   +1 more source

From lab to field : yield stability and shade avoidance genes are massively differentially expressed in the field [PDF]

, 2020
To unravel molecular mechanisms with the ultimate goal to achieve improved stress resilience or increased yield, plants are often studied under highly controlled conditions in which stresses are applied and in which growth‐ or architecture‐related traits
De Block, Jolien, De Vliegher, Alex, Demuynck, Kirin, Inzé, Dirk, Nelissen, Hilde, Sprenger, Heike, Van Hautegem, Tom   +6 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Combination of Nicorandil and Beta-Adrenergic Receptor Blockers in Patients with Coronary Artery Disease: A Real-World Observational Study

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
Background The effect of combined nicorandil and beta-adrenergic receptor blockers (BBs) compared with that of BBs alone on long-term clinical outcomes in patients with coronary artery disease (CAD) remains undetermined.
Jia Cheng MD, PhD, Lin Qiu MS, Zixuan Zhang MD, Na Li MD, Hongyang Shu MD, PhD, Zhichao Xiao MD, PhD, Ning Zhou MD, PhD   +6 more
doaj   +1 more source

Molecular mechanisms of parturition

Infectious Diseases in Obstetrics and Gynecology, 1997
The initial signal for triggering human parturition might be fetal but of trophoblastic origin. Concomitantly, this placental signal would have as its target not only the uterus but also the fetus by activating its hypothalamo-pituitary-adrenocortical axis.
openaire   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Photocarcinogenesis-molecular mechanisms

Collegium antropologicum, 2007
The carcinogenicity (photocarcinogenicity) of sunlight to human skin has been recognized more than a century ago. Last decades numerous experimental studies show that UV rays damage DNA, cause gene mutations leading to the development of malignant tumors such basal cell carcinomas, squamous cell carcinomas and melanomas.
Gruber, Franjo, Zamolo, Gordana, Kaštelan, Marija, Prpić Massari, Larisa, Čabrijan, Leo, Peharda, Vesna, Batinac, Tanja   +6 more
openaire   +3 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Cell Reports, 2020
Summary: PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the
Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer   +4 more
doaj   +1 more source