Results 71 to 80 of about 14,308,960 (385)
Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]
, 2013 Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
A Roy +42 more
core +3 more sources
The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility
Cells, 2022 Meiosis is a highly conserved specialized cell division process that generates haploid gametes. Many of its events are associated with dynamically regulated chromosomal structures and chromatin remodeling, which are mainly modulated by histone ...
Fernando Sánchez-Sáez +6 more
doaj +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
, 2016 Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam +4 more
core +1 more source
Cellular and Molecular Mechanisms of Metformin Action
Endocrine reviews, 2020 Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on glucose metabolism,
Traci E LaMoia, G. Shulman
semanticscholar +1 more source
Editorial : Autophagy : from big data to physiological significance [PDF]
, 2020 Autophagy is a fundamental catabolic process where cytoplasmic components are sequestered into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their content is degraded.
Nezis, Ioannis P. +2 more
core +1 more source
Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight
Cells, 2021 Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
doaj +1 more source
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Molecular mechanisms in haematological malignancies [PDF]
, 2009 Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto +2 more
core
Mechanisms of decoherence in weakly anisotropic molecular magnets
, 2000 Decoherence mechanisms in crystals of weakly anisotropic magnetic molecules, such as V15, are studied. We show that an important decohering factor is the rapid thermal fluctuation of dipolar interactions between magnetic molecules. A model is proposed to
A. Abragam +18 more
core +1 more source