Results 81 to 90 of about 14,308,960 (385)

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Nature Communications, 2016
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides ...
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga   +11 more
doaj   +1 more source

Regulation of Glucose Metabolism by NAD⁺ and ADP-Ribosylation

Cells, 2019
Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell
Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger   +2 more
doaj   +1 more source

Combination of Nicorandil and Beta-Adrenergic Receptor Blockers in Patients with Coronary Artery Disease: A Real-World Observational Study

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
Background The effect of combined nicorandil and beta-adrenergic receptor blockers (BBs) compared with that of BBs alone on long-term clinical outcomes in patients with coronary artery disease (CAD) remains undetermined.
Jia Cheng MD, PhD, Lin Qiu MS, Zixuan Zhang MD, Na Li MD, Hongyang Shu MD, PhD, Zhichao Xiao MD, PhD, Ning Zhou MD, PhD   +6 more
doaj   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Molecular Mechanisms of Preeclampsia [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease.
Hod T, Ana Sofia Cerdeira, Karumanchi Sa
openaire   +3 more sources

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Molecular mechanisms of preeclampsia [PDF]

Microvascular Research, 2008
Preeclampsia is a major cause of maternal, fetal and neonatal mortality worldwide. The mechanisms that initiate preeclampsia in humans have been elusive, but some parts of the puzzle have begun to come together. A key discovery in the field was the realization that its major phenotypes, such as hypertension and proteinuria, are due to excess ...
Walter P. Mutter, S. Ananth Karumanchi
openaire   +3 more sources

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source