Results 1 to 10 of about 35,562 (180)
CD38 as Immunotherapeutic Target in Light Chain Amyloidosis and Multiple Myeloma—Association With Molecular Entities, Risk, Survival, and Mechanisms of Upfront Resistance [PDF]
Frontiers in Immunology, 2018 Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs.
Anja Seckinger +12 more
doaj +4 more sources
Secretion of transthyretin: molecular mechanisms dependent on the endoplasmic reticulum [PDF]
Frontiers in PhysiologyHereditary transthyretin amyloidosis (ATTRv) results from genetic mutations that destabilize transthyretin (TTR), leading to the formation of extracellular aggregates and amyloid fibrils.
Jia Meng +4 more
doaj +2 more sources
Application of Radionuclide Myocardial Imaging in the Diagnosis and Treatment of Heart Failure With Preserved Ejection Fraction [PDF]
Reviews in Cardiovascular MedicineHeart failure with preserved ejection fraction (HFpEF) represents a major phenotype of heart failure and accounts for over 50% of clinical cases. The complex pathophysiological mechanism involved in HFpEF promotes diagnostic difficulties and limited ...
Yu Tian +4 more
doaj +2 more sources
Beyond perfusion: a review of peptide radiopharmaceuticals for cardiovascular imaging [PDF]
npj ImagingCardiology is continually evolving towards increased personalization with targeted diagnostics and therapeutics. Peptide-based radiopharmaceuticals have emerged as a valuable tool for noninvasive, receptor-specific imaging, addressing limitations of ...
Viktoria E. Krol +5 more
doaj +2 more sources
β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH. [PDF]
PLoS ONE, 2014 Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β2-microglobulin (β2m)
Sophia C Goodchild +8 more
doaj +5 more sources
Antibodies gone bad – the molecular mechanism of light chain amyloidosis [PDF]
The FEBS Journal, 2022 Light chain amyloidosis (AL) is a systemic disease in which abnormally proliferating plasma cells secrete large amounts of mutated antibody light chains (LCs) that eventually form fibrils. The fibrils are deposited in various organs, most often in the heart and kidney, and impair their function. The prognosis for patients diagnosed with AL is generally
Ramona M. Absmeier +4 more
openaire +4 more sources
Molecular Mechanisms of Cardiac Amyloidosis
International Journal of Molecular Sciences, 2021 Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved.
Yukihiro Saito +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2021 Substantial controversies exist in the exploration of the molecular mechanism of heart failure (HF) and pose challenges to the diagnosis of HF and the discovery of specific drugs for the treatment.
Shan He +13 more
doaj +1 more source
Cancer Medicine, 2023 Background Noncoding RNAs such as microRNAs (miRNAs) have attracted attention as biological pathway regulators, which differ from chromosomal translocations and gene point mutations.
Hila Fishov +10 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Exercise interventions are beneficial for reducing the risk of age-related diseases, including amyloidosis, but the underlying molecular links remain unclear. Here, we investigated the protective role of interval exercise training in a mouse model of age-
Xiaoran Cui +7 more
doaj +1 more source