Results 91 to 100 of about 36,527 (232)

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

SERUM AMYLOID A: A KEY MEDIATOR IN INFLAMMATION, METABOLIC DISORDERS AND CARDIOVASCULAR DISEASE [PDF]

Journal of IMAB
Introduction: Serum Amyloid A (SAA) is a critical acute-phase protein involved in a range of physiological and pathological processes, including inflammation, lipid metabolism, and the regulation of the immune system.
Ademira Borisova, Armine Grigoryan
doaj   +1 more source

Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. [PDF]

PLoS ONE, 2011
Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD,
Henrik Zetterberg, Erik Mörtberg, Linan Song, Lei Chang, Gail K Provuncher, Purvish P Patel, Evan Ferrell, David R Fournier, Cheuk W Kan, Todd G Campbell, Ray Meyer, Andrew J Rivnak, Brian A Pink, Kaitlin A Minnehan, Tomasz Piech, David M Rissin, David C Duffy, Sten Rubertsson, David H Wilson, Kaj Blennow   +19 more
doaj   +1 more source

Progress in Defining Blood Biomarkers for Alzheimer's Disease Based on Biochemical Mass Spectrometry Platforms

Organ Medicine, EarlyView.
Alzheimer's disease diagnosis relies on costly, invasive positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) analysis, limiting clinical use. This review summarizes a blood‐based biochemical mass spectrometry platform for early Alzheimer's disease (AD) detection, with non‐invasiveness, high sensitivity (fg/mL level), high ...
Yujian Xie, Wenjun Cai, Xiuying Zhao, Runqing Li   +3 more
wiley   +1 more source

\u3cem\u3eDe Novo\u3c/em\u3e [PSI\u3csup\u3e+\u3c/sup\u3e] Prion Formation Involves Multiple Pathways to Form Infectious Oligomers [PDF]

, 2017
Prion and other neurodegenerative diseases are associated with misfolded protein assemblies called amyloid. Research has begun to uncover common mechanisms underlying transmission of amyloids, yet how amyloids form in vivo is still unclear. Here, we take
Manogaran, Anita L., Merrill, Stephen J., Obaoye, Joanna O., Paulson, Emily, Sharma, Jaya, Wisniewski, Grett T.   +5 more
core   +1 more source

Why are Functional Amyloids Non-Toxic in Humans? [PDF]

, 2017
Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in ...
Hewitt, EW, Jackson, MP
core   +2 more sources

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

mtDNA copy number associated with age of onset in familial amyloid polyneuropathy [PDF]

, 2017
background Transthyretin-related familial amyloid polyneuropathy (TTR-Fap Val30Met) shows a wide variation in age-at-onset (aO) between generations and genders, as in portuguese families, where women display a later onset and a larger anticipation (>10 ...
Alonso, I, Alves-Ferreira, M, Coelho, T, Grazina, M, Lemos, C, Oliveira, P, Santos, D, Santos, MJ, Sequeiros, J, Sousa, A   +9 more
core   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

The Journal of Physiology, EarlyView.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark, Eric Rytkin, Andrei Alexandru Mircea, Igor R. Efimov   +3 more
wiley   +1 more source