Results 111 to 120 of about 36,527 (232)
ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala +1 more
wiley +1 more source
MODELIZATION OF AMYLOID FIBRIL SELF-ASSEMBLY
East European Journal of Physics, 2018 Intermolecular noncovalent interactions between protein molecules result in the formation of a wide spectrum of supramolecular assemblies the structure of which varies from disordered amorphous aggregates to the crystals with strictly defined ...
V. Trusova, G. Gorbenko
doaj
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides
Journal of Diabetes Research, 2015 Pancreatic islets in type 2 diabetes mellitus (T2DM) patients are characterized by reduced β-cells mass and diffuse extracellular amyloidosis.
Marianna Flora Tomasello +2 more
doaj +1 more source
Molecular Brain, 2010 Background It is hypothesized that complex interactions between multiple environmental factors and genetic factors are implicated in sporadic Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. Importantly, recent evidence
Devi Latha +3 more
doaj +1 more source
Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
VIEW, Volume 7, Issue 1, February 2026.Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley +1 more source
Molecular determinants and mechanisms of antibody light chain (AL) amyloidosis [PDF]
, 2016 Antibody light chain amyloidosis is a devastating protein misfolding disease where mostly light chain variable (VL) domains aggregate to amyloid fibrils, resulting in organ dysfunction and death. It is unclear which amino acid residues play a key role in governing VL fibrillation.
openaire
Aging Cell, Volume 25, Issue 2, February 2026.Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang +11 more
wiley +1 more source
Intracellular tracing of amyloid vaccines through direct fluorescent labelling
Scientific Reports, 2018 Alzheimer’s disease is a debilitating neurodegenerative condition that progressively causes synaptic loss and major neuronal damage. Immunotherapy utilising Aβ as an active immunogen or via passive treatment utilising antibodies raised to amyloid have ...
Matthew Mold +4 more
doaj +1 more source
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease [PDF]
, 2016 Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte and microglial reactivity, emerging evidence suggests a role of gut microbiota in regulating innate immunity ...
Chang, Eugene B +12 more
core +2 more sources