Results 121 to 130 of about 36,527 (232)

Low immunogenicity of insulin efsitora alfa in participants with type 1 and type 2 diabetes mellitus

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1350-1358, February 2026.
Abstract Aims To evaluate treatment‐emergent antidrug antibodies (TE ADA) in once‐weekly basal insulin efsitora‐treated participants with type 1 and type 2 diabetes mellitus (T1DM and T2DM) from 5 phase 3 clinical trials and their potential impact on pharmacokinetics, efficacy and safety.
Yun Wang, Sihe Wang, Wei Wang, Xiaoqi Li, Jennifer Leohr, Vitoria Pires, Michelle L. Katz, Christopher J. Child, Robert J. Konrad   +8 more
wiley   +1 more source

Nanoparticles and siRNA: A new era in therapeutics?

Pharmacological Research
Since its discovery in 1998, the use of small interfering RNA (siRNA) has been increasing in biomedical studies because of its ability to very selectively inhibit the expression of any target gene.
María Dolores Pérez-Carrión, Inmaculada Posadas, Valentín Ceña   +2 more
doaj   +1 more source

Selection for Function in Complex Distributed Pathological Systems

Evolutionary Applications, Volume 19, Issue 2, February 2026.
ABSTRACT Pathological processes are often conceptualized as localized phenomena anchored in a primary tumor, a focal lesion, or a single organ. However, growing evidence indicates that many diseases persist and progress as complex distributed systems, maintained by interactions among multiple sites.
Frédéric Thomas, Antoine M. Dujon, Daniel Vaiman, Gerard Eberl, Catherine Alix‐Panabières, Pascal Pujol, Beata Ujvari, Jordan Meliani, Aurora M. Nedelcu, Jean‐Pascal Capp   +9 more
wiley   +1 more source

Protein tandem repeats that produce frameshifts can generate new structural states and functions

The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.
We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli, Gudrun Aldrian, Jeremy Leclercq, Theo Falgarone, Santiago M. Gómez Bergna, Denis N. Prada Gori, Andrew V. Oleinikov, Ilham Shahmuradov, Andrey V. Kajava   +8 more
wiley   +1 more source

Snapshot Look at Castleman Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Castleman disease (CD) is a rare and heterogeneous group of lymphoproliferative disorders characterised by abnormal proliferation of lymphoid tissue. First described in the 1950s, it has since been classified into two major clinical forms: unicentric CD (UCD), involving a single lymph node region and multicentric CD (MCD), which affects ...
Ciprian Jitaru, Natalia Zlampa, Delia Dima, Anca Bojan, Mihnea Zdrenghea, Laura Urian, David Kegyes, Anamaria Bancos, Maria Santa, Andrei Ivancuta, Bobe Petrushev, Madalina Nistor, Bogdan Tigu, Catalin Constantinescu, Bogdan Fetica, Maria Puiu, Mihai‐Stefan Muresan, Ciprian Tomuleasa   +17 more
wiley   +1 more source

Tranexamic Acid for Hyperpigmentation Disorders: A Literature Review on Efficacy and Safety in Melasma and PIH

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hyperpigmentation disorders, including melasma and post‐inflammatory hyperpigmentation (PIH), are common dermatologic conditions associated with significant cosmetic and psychological burden. Tranexamic acid (TXA), an antifibrinolytic agent, has gained increasing attention due to its anti‐inflammatory and antimelanogenic properties.
Ahmed AlJabr, Aseel Muhana I. AlAnazi, Rakan Abdulkarim A. AlEtebi   +2 more
wiley   +1 more source

Amiloidose renal: classificação de 102 casos consecutivos [PDF]

, 2014
Amyloidoses are a group of heterogeneous diseases classified according to the nature of their causative amyloid proteins. Commonly, paraffin-embedded tissue is used for the typing of amyloid by immunohistochemistry.
Lobato, L., Moreira, L., Oliveira, J., Pereira, P., Pinho-Costa, P., Sampaio, S., Tavares, I., Vaz, R., Vizcaíno, J.   +8 more
core  

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Cardiac functional and structural impairments, endothelial apoptosis and blood-brain barrier dysfunction in models of cerebrovascular amyloidosis in the presence or absence of hyperhomocysteinemia

Cerebral Circulation - Cognition and Behavior
Cerebrovascular dysfunction has been implicated as a major early contributor to Alzheimer's Disease (AD) pathology, with endothelial cell (EC) stress resulting in focal ischemia, cerebral blood flow impairments, and blood brain barrier (BBB) permeability.
Ashley Carey, Andrea Elia, Rebecca Parodi-Rullan, Silvia Fossati   +3 more
doaj   +1 more source

Kidney disease impairs tendon function in rats

The Journal of Physiology, Volume 604, Issue 3, Page 1113-1136, 1 February 2026.
Abstract figure legend This study demonstrates for the first time that tendon strength is reduced in a rodent model of chronic kidney disease (8 weeks of 0.25% adenine feeding) and confirms concurrent dysfunction in muscle and bone. These findings provide novel characterization of multiple tissues, paving the way for future investigations into the ...
Christopher M. T. Hayden, Natalie K. Gilmore, Benjamin Osipov, Sarah E. Brashear, Marc Gorge, Juang‐Yu Jen, Lucas R. Smith, Blaine A. Christiansen, Baback Roshanravan, Keith Baar   +9 more
wiley   +1 more source