Results 11 to 20 of about 36,527 (232)

Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas

Molecules, 2022
Amyloidosis is a common pathological event in which proteins self-assemble into misfolded soluble and insoluble molecular forms, oligomers and fibrils that are often toxic to cells.
Diti Chatterjee Bhowmick, Zhanar Kudaibergenova, Lydia Burnett, Aleksandar M. Jeremic   +3 more
doaj   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
semanticscholar   +2 more sources

Serum amyloid A and protein AA: Molecular mechanisms of a transmissible amyloidosis [PDF]

FEBS Letters, 2009
Systemic AA‐amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA‐amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils.
Westermark, Gunilla T., Westermark, Per
openaire   +3 more sources

Exploring the Molecular Pathology of Iatrogenic Amyloidosis

Journal of Molecular Pathology
Iatrogenic amyloidosis results from medical therapeutic interventions, leading to the misfolding and aggregation of proteins into amyloid fibrils or to their direct deposition in different tissues.
Bernardo Bonilauri
doaj   +2 more sources

Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43

Aging and disease, 2023
FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear ribonucleoprotein family, have gained significant attention in the field of neurodegenerative diseases due to their association with amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD).
Jianxing Song
openaire   +3 more sources

Serum Inflammatory Profile in Hereditary Transthyretin Amyloidosis: Mechanisms and Possible Therapeutic Implications

Brain Sciences, 2022
Hereditary transthyretin (ATTRv) amyloidosis is a severe, progressive, and heterogeneous multisystemic condition due to mutations in the TTR gene. Although multiple aspects of its molecular pathophysiological mechanisms have been elucidated over the ...
Marco Luigetti, Angela Romano, Valeria Guglielmino, Maria Ausilia Sciarrone, Francesca Vitali, Carmine Carbone, Geny Piro, Andrea Sabino, Nicola De Stefano, Domenico Plantone, Guido Primiano   +10 more
doaj   +2 more sources

Current and New Perspectives on the Molecular and Cellular Mechanisms of Amyloid Formation and Toxicity in Light Chain Amyloidosis [PDF]

, 2011
Light chain (AL) amyloidosis is a protein misfolding disease characterized by the abnormal proliferation of monoclonal plasma cells that secrete free immunoglobulin light chains (LC) into circulation. These LCs misfold and aggregate as amyloid fibrils in vital organs.
DiCostanzo, Ara Celi, Ramirez-Alvarado, Marina   +1 more
openaire   +3 more sources

EXPLORING THE MOLECULAR AND BIOPHYSICAL MECHANISMS OF PROTEOTOXIC IMMUNOGLOBULIN LIGHT CHAINS IN AL AMYLOIDOSIS

, 2019
Herein, immunoglobulin light chains (LCs) native state was studied in the context of the pathology known as light chain amyloidosis (AL). This pathology is characterized by LCs overexpression, which leads to toxicity and aggregation into amyloid fibrils in target organs, with heart being the most affected one.
S. Ricagno, Oberti Luca
openaire   +3 more sources

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

Aggregate
Protein aggregation drives proteinopathies ranging from ALS to systemic amyloidosis, yet the multiscale determinants bridging sequence, structure, and kinetics remain elusive.
Wei Xuan Wilson Loo, Jia Shen Sio, Keyin Yap, Yan Shan Loo, Hui Xuan Lim, Shuangyue Zhang, Huitao Liu, Chen Seng Ng   +7 more
doaj   +2 more sources

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Journal of Neuroinflammation
Background Alzheimer’s disease (AD) is characterized by progressive amyloid beta (Aβ) deposition in the brain, with eventual widespread neurodegeneration.
Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, David R. Kaplan, Freda D. Miller, Brian A. MacVicar, Haakon B. Nygaard   +18 more
doaj   +2 more sources