Results 191 to 200 of about 36,527 (232)

Molecular Mechanisms of Amyloidosis

New England Journal of Medicine, 2003
Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication of dialysis, and also causes rare conditions. The many forms of the disorder have one underlying principle: misfolded proteins. Prompt, correct diagnosis is essential, especially in the inherited forms of amyloidosis.
MERLINI, GIAMPAOLO, BELLOTTI, VITTORIO
semanticscholar   +8 more sources

New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis

British Journal of Dermatology, 2009
Macular and lichen amyloidosis are common variants of primary localized cutaneous amyloidosis (PLCA) in which clinical features of pruritus and skin scratching are associated with histological findings of deposits of amyloid staining on keratinous debris in the papillary dermis.
Tanaka, A., Arita, K., Lai-Cheong, J. E., Palisson, F., Hide, M., McGrath, J. A.   +5 more
openaire   +4 more sources

β-Amyloidosis in the pathogenesis of Alzheimer's disease - possible molecular mechanisms

European Neuropsychopharmacology, 1994
Abstract Proteolytic production and deposition of β-amyloid peptide is an early sign of pathology in the brains of Alzheimer's disease patients. This may result not only in disturbance of β-amyloid precursor protein (β-APP) functions but also in accumulation of a harmful, neurotoxic peptide product.
G. Huber, H. Döbeli, M. Gschwind, J. Löffler, J.R. Martin, J.-L. Moreau   +5 more
openaire   +2 more sources

Special Issue: The Molecular and Cellular Mechanisms of Amyloidosis

Journal of Molecular Biology, 2012
Sheena E, Radford, Jonathan S, Weissman
openaire   +3 more sources

Faculty Opinions recommendation of AL amyloidosis: from molecular mechanisms to targeted therapies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
P. Hari
openaire   +2 more sources

Abstract B112: SNAP23-dependent SNARE complex is a novel molecular target in AL Amyloidosis and Multiple Myeloma by blocking free light chain secretion and triggering a terminal unfolded protein response

Molecular Cancer Therapeutics, 2023
The goal of this study was to investigate whether SNARE proteins are necessary for immunoglobulin (Ig) free light chain (FLC) secretion, thus representing a yet unexplored therapeutic target in AL amyloidosis (AL) and Multiple myeloma (MM).
Emre Karayol, Maria Moscvin, Tianzeng Chen, Peter G. Czarnecki, Annamaria Gullà, Kenneth C. Anderson, G. Bianchi   +6 more
semanticscholar   +1 more source

Computational Dissection of the Polypharmacology of a Ganoderma-Eupolyphaga-Cordyceps-Paeonia Decoction for Secondary Amyloidosis TreatmentA Network Pharmacology and Molecular Docking StudyMulti-Target Mechanisms of GECP against Secondary Amyloidosis

Proceedings of the 2025 6th International Symposium on Artificial Intelligence for Medical Sciences
Objective: We elucidated the potential molecular mechanisms by which the compound decoction (GECP), composed of Ganoderma lucidum, Eupolyphaga sinensis, Cordyceps cicadae, and Paeonia lactiflora, modulates secondary amyloidosis (SA) using network ...
Jiale Chai, Yuanqi Cai, Shuzhi Qin
semanticscholar   +1 more source

Molecular Mechanisms Of Beta-Amyloid Blockage Under The Action Of Natural Compounds And Its Nanoformulations

2024 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
Amyloidosis represents serious disease caused by the amyloid protein deposition in many tissues and organs, including heart, brain, vessels, nerves, etc.
Svetlana N. Morozkina, P. Snetkov, M. V. Uspenskaya   +2 more
semanticscholar   +1 more source

Distinct disruption mechanisms of green tea extracts EGC and EGCG on ATTR fibrils: a molecular simulation study.

Physical Chemistry, Chemical Physics - PCCP
Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is a life-threatening disease caused by misfolded TTR amyloid fibril deposition. Disaggregating these fibrils is a promising treatment method.
Xingke Yan, Yuanming Cao, Zihan Xu, Yanyan Zhu, Qingjie Zhao, Huiyu Li, Yujie Chen   +6 more
semanticscholar   +1 more source

Inhibition of fibril formation by polyphenols: molecular mechanisms, challenges, and prospective solutions.

Chemical Communications
Fibril formation is a key feature in neurodegenerative diseases like Alzheimer's, Parkinson's, and systemic amyloidosis. Polyphenols, found in plant-based foods, show promise in inhibiting fibril formation and disrupting disease progression.
Shilpa Sharma, S. Deep
semanticscholar   +1 more source