Results 201 to 210 of about 36,527 (232)
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Understanding the Molecular Mechanism of Plasma Cell Clonality and Disease Evolution in Light Chain Amyloidosis

Blood
Amyloidosis, also known as light chain amyloidosis (AL), is one of the most common types of systemic amyloidosis affecting patients of older ages with a median age of 64 years. Nearly 4000 new cases are diagnosed annually in the US alone (Dima et. al. JCO Oncology Practice 2023).
Yahan Zhang   +5 more
openaire   +1 more source

Bridging Pancreatic Amyloidosis and Neurodegeneration: The Emerging Role of Amylin in Diabetic Dementia

International Journal of Molecular Sciences
A hallmark of type 2 diabetes mellitus (T2DM) is the presence of abundant amyloid deposits composed of amyloid polypeptide (amylin) within the pancreatic islets of Langerhans.
Gourav Shome   +5 more
semanticscholar   +1 more source

Pulmonary Amyloidosis

Seminars in Respiratory and Critical Care Medicine
Amyloidosis is a heterogeneous group of rare diseases characterized by the deposition of misfolded and insoluble proteins in tissues. Lung involvement, airways or parenchyma, is relatively common, but usually mild.
S. Levra, Marcel Opitz, F. Bonella
semanticscholar   +1 more source

Integrated transcriptomic and proteomic analysis of clonal plasma cells from patients with AL amyloidosis

Blood
Systemic AL amyloidosis is a rare disease caused by the abnormal extracellular deposition of misfolded immunoglobulin light chain fibrils that lead to organ dysfunction and failure.
Ourania Theologi   +16 more
semanticscholar   +1 more source

MAPK pathway-driven metabolic-inflammatory axis in AL amyloidosis

Blood
Introduction Systemic light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains in vital organs, often resulting in irreversible organ damage.
Tal Zvida-Bloch   +13 more
semanticscholar   +1 more source

Patient-derived amyloidogenic light chain triggers cardiovascular toxicity In Vivo and reveals ICAM-1 as a novel potential biomarker in patients with AL amyloidosis

Blood
Background and aims: In light chain (AL), the circulating immunoglobulin light chains (LCs) have been suggested to provoke cardiotoxicity. We aimed to characterize the underlying mechanisms of LC-mediated cardiotoxicity in vivo to identify novel ...
P. Nikolaou   +9 more
semanticscholar   +1 more source

Mechanistic insights into light chain-associated cardiotoxicity: from amyloidosis patient-derived light chains to animal models

European Heart Journal
Light chain amyloidosis (AL), is a plasma cell dyscrasia in which cardiac involvement determines the prognosis. Immunoglobulin light chains (LCs) have been suggested to provoke cardiotoxicity.
P. Nikolaou   +14 more
semanticscholar   +1 more source

Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, 2021
Xuejun Jiang   +2 more
exaly  

Photodynamic therapy of cancer: An update

Ca-A Cancer Journal for Clinicians, 2011
Patrizia M Agostinis   +2 more
exaly  

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