Results 21 to 30 of about 36,527 (232)
Primary (AL) Amyloidosis Following COVID-19 Infection: A Case Report. [PDF]
Clin Case RepABSTRACT Primary (AL) amyloidosis is a rare systemic disorder caused by extracellular deposition of monoclonal immunoglobulin light chains, resulting in multi‐organ dysfunction. SARS‐CoV‐2 infection may induce persistent inflammatory and immune dysregulation, potentially promoting amyloid formation, although clinical evidence is limited, making the ...
Gholami N +4 more
europepmc +2 more sources
Frontiers in Molecular Biosciences, 2021 Monomer dissociation and subsequent misfolding of the transthyretin (TTR) is one of the most critical causative factors of TTR amyloidosis. TTR amyloidosis causes several human diseases, such as senile systemic amyloidosis and familial amyloid ...
Wonjin Yang +9 more
doaj +1 more source
Molecular Mechanism of Pathogenesis and Treatment Strategies for AL Amyloidosis
International Journal of Molecular Sciences, 2022 In amyloid light-chain (AL) amyloidosis, small B-cell clones (mostly plasma cell clones) present in the bone marrow proliferate and secrete unstable monoclonal free light chains (FLCs), which form amyloid fibrils that deposit in the interstitial tissue, resulting in organ injury and dysfunction. AL amyloidosis progresses much faster than other types of
Hidehiko Ikura +5 more
openaire +2 more sources
eLife, 2021 Curcumin is a polyphenol compound that exhibits multiple physiological activities. To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid ...
Jian Dai +8 more
doaj +1 more source
Human apolipoprotein A-I natural variants: molecular mechanisms underlying amyloidogenic propensity. [PDF]
PLoS ONE, 2012 Human apolipoprotein A-I (apoA-I)-derived amyloidosis can present with either wild-type (Wt) protein deposits in atherosclerotic plaques or as a hereditary form in which apoA-I variants deposit causing multiple organ failure.
Nahuel A Ramella +7 more
doaj +1 more source
Arrhythmic Burden in Cardiac Amyloidosis: What We Know and What We Do Not
Biomedicines, 2022 Cardiac amyloidosis (CA), caused by the deposition of insoluble amyloid fibrils, impairs different cardiac structures, altering not only left ventricle (LV) systo-diastolic function but also atrial function and the conduction system.
Alessia Argirò +9 more
doaj +1 more source
Molecular mechanisms of neurodegenerative disease (NDD)
AIMS Molecular Science, 2023 Degenerative nerve diseases affect body's balance, movement, speech, breathing and heart function. Classification of neurodegenerative disorders can be done on the basis of their molecular cause, like abnormal protein aggregation, involved cell death or
A. Chakraborty, Anil Diwan
semanticscholar +1 more source
Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. [PDF]
PLoS Genetics, 2010 Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein-protein interactions; however, its relevance to disease processes is not clear.
Amir N Saleem +14 more
doaj +1 more source
Life, 2022 Incoherent neutron scattering (iNS) is one of the most powerful techniques to study the dynamical behavior of bio-macromolecules such as proteins and lipid molecules or whole cells. This technique has widely been used to elucidate the fundamental aspects
Tatsuhito Matsuo, Judith Peters
doaj +1 more source
The molecular landscape of AL amyloidosis. [PDF]
Br J HaematolAmyloid light‐chain (AL) amyloidosis is a systemic clonal plasma cell disorder characterized by the production and deposition of misfolded immunoglobulin light chains (LCs), resulting in multiorgan dysfunction.
Zvida-Bloch T +4 more
europepmc +2 more sources