Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]
, 2016 The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T +11 more
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MetAmyl: a METa-predictor for AMYLoid proteins. [PDF]
PLoS ONE, 2013 The aggregation of proteins or peptides in amyloid fibrils is associated with a number of clinical disorders, including Alzheimer's, Huntington's and prion diseases, medullary thyroid cancer, renal and cardiac amyloidosis.
Mathieu Emily +2 more
doaj +1 more source
Pharmacological Research - Modern Chinese Medicine, 2023 Introduction: High altitude cognitive dysfunction (HACD) is a type of cognitive impairment that is associated with exposure to high-altitude environments. This condition is characterized by deficits in attention, memory, learning, executive function, and
Ling Yang +5 more
doaj +1 more source
Ursodeoxycholic acid for treatment of cholestasis in patients with hepatic amyloidosis [PDF]
, 2009 Background. Amyloidosis represents a group of different diseases characterized by extracellular accumulation of pathologic fibrillar proteins in various tissues and organs.
Akoglu Bora +3 more
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Journal of Disability Research, 2023 The study aims to examine the aggregation of proteins due to their association with various conformational problems including well-known neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
Nada H. Aljarba +3 more
doaj +1 more source
Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]
, 2008 Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky +7 more
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Novel Therapies in Light Chain Amyloidosis
Kidney International Reports, 2018 Light chain (AL) amyloidosis is the most common form of amyloidosis involving the kidney. It is characterized by albuminuria, progressing to overt nephrotic syndrome and eventually end-stage renal failure if diagnosed late or ineffectively treated, and ...
Paolo Milani +2 more
doaj +1 more source
The non-coding RNA landscape of plasma cell dyscrasias [PDF]
, 2020 Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat.
Azab, Kareem A +3 more
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Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
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Clinical and Experimental Nephrology, 2018 Uremic toxins are linked to chronic kidney disease (CKD)-related systemic diseases. β2-Microglobulin (β2-m), a water-soluble, middle-sized molecule, is associated with mortality and dialysis-related amyloidosis (DRA).
Suguru Yamamoto
semanticscholar +1 more source