Results 51 to 60 of about 36,527 (232)
Natural history and outcome in systemic AA amyloidosis [PDF]
, 2007 BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Gallimore, JR +6 more
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Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice [PDF]
, 2009 The SpAs are a group of overlapping, chronic, inflammatory rheumatic diseases including AS, a chronic inflammatory disease primarily affecting the SI joints.
Elewaut, Dirk, Matucci-Cerinic, Marco
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Pharmacogenomics and Personalized Medicine, 2020 Wenxiang Bai,1,2,* Honghua Wang,1,* Hua Bai1,3 1Comprehensive Cancer Center, Xiangshui People’s Hospital, Xiangshui 224600, People’s Republic of China; 2Department of Respiratory Medicine, Xiangshui People’s Hospital, Xiangshui, 224600,
Bai W, Wang H, Bai H
doaj
Darwinian transformation of a 'scarcely nutritious fluid' into milk [PDF]
, 2012 In an early challenge to an aspect of Darwin’s theory of natural selection, Jackson Mivart contended that milk could not have evolved ‘from a scarcely nutritious fluid from an accidentally hypertrophied cutaneous gland’.
Carver, J.A., Holt, C.
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The FASEB Journal, 2013 Plasma high‐density lipoproteins (HDL) are nanoassemblies of lipids and specific proteins, mainly apolipoprotein A‐I (apoA‐I, 243 a. a.). HDL and apoA‐I remove excess cell cholesterol and protect against atherosclerosis. In familial amyloidosis, mutant apoA‐I is proteolysed and the N‐terminal ~10 kDa fragments deposit as fibrils in vital organs ...
Madhurima Das +3 more
openaire +1 more source
Corino de Andrade disease: mechanisms and impact on reproduction [PDF]
, 2017 Familial amyloid polyneuropathy was first described by Corino de Andrade in 1952 in Northern Portugal. It is a fatal autosomal dominant neurodegenerative disorder characterized by a progression of neurologic symptoms, beginning early in the reproductive ...
Barros, A. +3 more
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Journal of Alzheimer's Disease Reports, 2018 Aβ40 and Aβ42 peptides are believed to be associated with Alzheimer’s disease. Aggregates (plaques) of Aβ fibrils are found in the brains of humans affected with this disease. The mechanism of formation of Aβ fibrils has not been studied completely, which hinders the development of a correct strategy for therapeutic prevention of this ...
Galzitskaya, Oxana V. +4 more
openaire +3 more sources
The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design. [PDF]
, 2019 The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Akter, Rehana +4 more
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Reviews in Cardiovascular MedicineCardiac amyloidosis (CA) represents an increasingly recognized but historically underdiagnosed cause of restrictive cardiomyopathy and heart failure. CA is now understood to be more prevalent, particularly in older adults, as advancements in imaging and ...
Karim Ali +7 more
doaj +1 more source
Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures [PDF]
, 2016 BACKGROUND: Early diagnosis of familial transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease-modifying therapies ...
Buxbaum, J. +7 more
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