Results 91 to 100 of about 3,774,726 (329)

HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amino ...
P. Gourh, Sarah A. Safran, Theresa A. Alexander, S. Boyden, Nadia D. Morgan, Ami A. Shah, M. Mayes, A. Doumatey, A. Bentley, D. Shriner, R. Domsic, T. Medsger, Paula S. Ramos, R. Silver, V. Steen, J. Varga, V. Hsu, L. Saketkoo, E. Schiopu, D. Khanna, J. Gordon, Brynn Kron, L. Criswell, H. Gladue, C. Derk, E. Bernstein, S. L. Bridges, V. Shanmugam, K. Kolstad, L. Chung, S. Kafaja, R. Jan, M. Trojanowski, A. Goldberg, B. Korman, P. Steinbach, S. Chandrasekharappa, J. Mullikin, A. Adeyemo, C. Rotimi, F. Wigley, D. Kastner, F. Boin, E. Remmers   +43 more
semanticscholar   +1 more source

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

To the problem of spectral mimicry of supergiants [PDF]

, 2017
The phenomenon of spectral mimicry refers to the fact that hypergiants and post-AGB supergiants - stars of different masses in fundamentally different stages of their evolution have similar optical spectra, and also share certain other characteristics (unstable and extended atmospheres, expanding gas-dust envelopes, high IR excesses). As a consequence,
arxiv   +1 more source

A Response to Glaze Purification via IMPRESS [PDF]

arXiv, 2023
Recent work proposed a new mechanism to remove protective perturbation added by Glaze in order to again enable mimicry of art styles from images protected by Glaze. Despite promising results shown in the original paper, our own tests with the authors' code demonstrated several limitations of the proposed purification approach.
arxiv  

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis

Advanced Healthcare Materials, EarlyView.
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu, Joel M. Yong, Robyn Yeh, Florence Bartlett, John M. Whitelock, Megan S. Lord   +5 more
wiley   +1 more source

Umpolung Synthesis of Pyridyl Ethers by BiV‐Mediated O‐Arylation of Pyridones

Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022
We demonstrate that sterically‐ and electronically‐diverse pyridyl ethers can be accessed via BiV‐mediated C−O coupling of 2‐ or 4‐pyridones with arylboronic acids. Use of a bismacyclic reagent not only confers modularity on our methodology, but also results in highly regioselective O‐arylation that is unprecedented for BiV.
Katie Ruffell, Liliana C. Gallegos, Kenneth B. Ling, Robert S. Paton, Liam T. Ball   +4 more
wiley   +2 more sources

Inflammasome Molecular Insights in Autoimmune Diseases

Current Issues in Molecular Biology
Autoimmune diseases (AIDs) emerge due to an irregular immune response towards self- and non-self-antigens. Inflammation commonly accompanies these conditions, with inflammatory factors and inflammasomes playing pivotal roles in their progression.
Monica Neamțu, Veronica Bild, Alexandru Vasincu, Oana Dana Arcan, Delia Bulea, Daniela-Carmen Ababei, Răzvan-Nicolae Rusu, Ioana Macadan, Ana Maria Sciucă, Andrei Neamțu   +9 more
doaj   +1 more source

A Bio‐Inspired Perspective on Materials Sustainability

Advanced Materials, EarlyView.
This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier, Khashayar Razghandi, Peter Fratzl   +2 more
wiley   +1 more source

Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry.

Frontiers in Oncology, 2012
Surgery, chemotherapy, and radiation therapy are standard modalities for cancer treatment, but the effectiveness of these treatments has reached a plateau. Thus, other strategies are being explored to combine with the current treatment paradigms in order
Ana María eHernández, Nely eRodríguez-Zhurbenko, Ana María eVázquez   +2 more
doaj   +1 more source

Supramolecular Chemistry in Metal–Organic Framework Materials

Advanced Materials, EarlyView.
This review highlights synergies between reticular chemistry and supramolecular chemistry. The role of supramolecular interactions in determining framework…guest interactions and attempts to understand dynamic behavior in metal–organic frameworks (MOFs), particularly emphasizing the development of crystal sponges, studying reactions in frameworks and ...
Eugenia Miguel‐Casañ, Georgia R. F. Orton, Danielle E. Schier, Neil R. Champness   +3 more
wiley   +1 more source