Results 191 to 200 of about 3,798,746 (339)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]

, 2009
The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs, Ejrnaes, Mette, Herrath, Matthias G. von   +2 more
core  

Molecular mimicry and immune thrombocytopenia

Blood, 2009
In this issue of Blood, Zhang and colleagues show evidence that many thrombocytopenic patients infected with HCV have autoantibodies specific for a defined peptide sequence in platelet membrane glycoprotein IIIa. These autoantibodies appear to be the result of an immune response mounted against one or more peptides present in the HCV core envelope ...
openaire   +3 more sources

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Advanced Science, EarlyView.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe   +13 more
wiley   +1 more source

ABO System: molecular mimicry of Ascaris lumbricoides

Revista do Instituto de Medicina Tropical de São Paulo, 2003
A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients.
Ponce de León Patricia, Valverde Juana
doaj  

IgA cross-reactivity between a nuclear autoantigen and wheat proteins suggests molecular mimicry as a possible pathomechanism in celiac disease [PDF]

, 2001
Susanne Natter, G Granditsch, G. Reichel, Mehrdad Baghestanian, Peter Valent, Lena Elfman, Hans Grönlund, Dietrich Kraft, Rudolf Valenta   +8 more
openalex   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

In silico analysis of molecular mimicry between human aquaporin 3, Aspergillus fumigatus aquaporin and aquaporins from allergic sources.

Revista Alergia México
Background: Atopic dermatitis (AD) profoundly impacts quality of life as a chronic inflammatory skin disease. Allergen exposure triggers specific IgE antibodies, initiating allergy symptoms. Cross-reactivity, linked to auto-IgE responses, potentially
Andres Sanchez, Yaquelin Padilla, Adriana Lorduy, Jorge Sanchez, Marlon Munera, Claudia Baena, Carlos Bernal, Juan Urrego   +7 more
doaj   +1 more source

Virus-induced autoimmunity: Molecular mimicry as a route to autoimmune disease

, 1989
Michael B. A. Oldstone
openalex   +1 more source

Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry [PDF]

, 2001
Gustavo Mostoslavsky, Ruth Fischel, Nurit Yachimovich, Yuval Yarkoni, E. Rosenmann, Marc Monestier, Michal Baniyash, Dan Eilat   +7 more
openalex   +1 more source