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Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19

Cell stress & chaperones (Print), 2020
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the cause of COVID-19 disease, has the potential to elicit autoimmunity because mimicry of human molecular chaperones by viral proteins.
A. Marino Gammazza, Sébastien Légaré, Giosuè Lo Bosco, A. Fucarino, F. Angileri, E. Conway de Macario, A. Macario, F. Cappello   +7 more
semanticscholar   +1 more source

SARS-CoV-2-Induced Immunosuppression: A Molecular Mimicry Syndrome

Global Medical Genetics, 2022
Background Contrary to immunological expectations, decay of adaptive responses against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) characterizes recovered patients compared with patients who had a severe disease course or died following ...
Darja Kanduc
doaj   +1 more source

Role of Mycobacterium paratuberculosis infection in etiopathogenesis of type 1 diabetes: A review of population-based studies

Journal of Diabetology, 2023
Introduction: Multiple mechanisms were proposed for the etiopathogenesis of type 1 diabetes mellitus (T1DM). An interplay between genetic, environmental, and immunological factors leads to generate autoantibodies against glutamic acid decarboxylase 65 ...
Ashish Gautam, Shoor Vir Singh, Saurabh Gupta, Nikhil Pursnani, Prabhat Agrawal   +4 more
doaj   +1 more source

Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis

Journal of Clinical Medicine, 2020
Viruses can generate molecular mimicry phenomena within their hosts. Why should severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?
F. Cappello, A. Marino Gammazza, F. Dieli, E. Conway de Macario, A. Macario   +4 more
semanticscholar   +1 more source

Carbohydrate Mimetic Peptides for Pan Anti-Tumor Responses

Frontiers in Immunology, 2014
Molecular mimicry is fundamental to biology which transcends to many disciplines ranging from immune pathology to drug design. Structural characterization of molecular partners has provided insight into the origins and relative importance of ...
Thomas eKieber-Emmons, Anastas ePashov, Somdutta eSaha, Behjatolah eMonzavi-Karbassi, Ramachandran eMurali   +4 more
doaj   +1 more source

Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens

Arquivos de Neuro-Psiquiatria, 2023
Background Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV ...
Laise Carolina França, Fabrícia Lima Fontes-Dantas, Diogo Gomes Garcia, Amanda Dutra de Araújo, João Paulo da Costa Gonçalves, Cláudia Cecília da Silva Rêgo, Elielson Veloso da Silva, Osvaldo José Moreira do Nascimento, Fernanda Cristina Rueda Lopes, Alice Laschuk Herlinger, Renato Santana de Aguiar, Orlando da Costa Ferreira Junior, Fernando Faria Andrade Figueira, Jorge Paes Barreto Marcondes de Souza, Joelma Freire De Mesquita, Soniza Vieira Alves-Leon   +15 more
doaj   +1 more source

Intruders in disguise: Mimicry effect in granular gases [PDF]

Phys. Fluids 31, 063306 (2019), 2019
In general, the total kinetic energy in a multicomponent granular gas of inelastic and rough hard spheres is unequally partitioned among the different degrees of freedom. On the other hand, partial energy equipartition can be reached, in principle, under appropriate combinations of the mechanical parameters of the system.
arxiv   +1 more source

Does the Goal Matter? Emotion Recognition Tasks Can Change the Social Value of Facial Mimicry towards Artificial Agents [PDF]

Frontiers in Robotics and AI, 8, 362 (2021), 2021
In this paper, we present a study aimed at understanding whether the embodiment and humanlikeness of an artificial agent can affect people's spontaneous and instructed mimicry of its facial expressions. The study followed a mixed experimental design and revolved around an emotion recognition task.
arxiv   +1 more source

Is molecular mimicry the culprit in the autoimmune haemolytic anaemia affecting patients with COVID‐19?

British Journal of Haematology, 2020
This Journal recently published two papers describing autoimmune hemolytic anemia (AIHA) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1, 2).
F. Angileri, Sébastien Légaré, A. Marino Gammazza, E. Conway de Macario, A. Macario, F. Cappello   +5 more
semanticscholar   +1 more source

The impact of antigenic molecular mimicry on anti-cancer T-cell immune response

Frontiers in Oncology, 2022
Individuals are exposed to intracellular pathogens (i.e. viruses and intracellular bacteria) and intestinal microbiota, collectively microorganisms (MOs), which enter the body during the host’s lifetime.
Maria Tagliamonte, Luigi Buonaguro
doaj   +1 more source