Results 101 to 110 of about 98,232 (273)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multi‐state photoluminescent properties of an overcrowded alkene‐based molecular motor in aggregates

Aggregate
Photoisomerization and photoluminescence are two distinct energy dissipation pathways in light‐driven molecular motors. The photoisomerization properties of discrete molecular motors have been well established in solution, but their photoluminescent ...
Yahan Shan, Jinyu Sheng, Qi Zhang, Marc C. A. Stuart, Da‐Hui Qu, Ben L. Feringa   +5 more
doaj   +1 more source

Cooperative Cargo Transport by Several Molecular Motors

, 2005
The transport of cargo particles which are pulled by several molecular motors in a cooperative manner is studied theoretically. The transport properties depend primarily on the maximal number, $N$, of motor molecules that may pull simultaneously on the ...
Ashkin, Bell, Block, B  hm, Erdmann, Goldstein, Hill, Kuznetsov, Lipowsky, Miller, R. Lipowsky, S. Klumpp, Schnitzer, Seitz, Shah, Svoboda, Trinczek, Vale, Visscher, Wang   +19 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle

Nature Communications
Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive.
Chapin S. Korosec, Ivan N. Unksov, Pradheebha Surendiran, Roman Lyttleton, Paul M. G. Curmi, Christopher N. Angstmann, Ralf Eichhorn, Heiner Linke, Nancy R. Forde   +8 more
doaj   +1 more source

Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors

, 2014
Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials.
Kolomeisky, Anatoly B., Mehrabiani, Kareem, Teimouri, Hamid   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

Bioengineering, 2017
In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i)
Ramana M. Pidaparti, Charles Cartin, Guoguang Su   +2 more
doaj   +1 more source

Molecular Motors: Dynein's Gearbox [PDF]

Current Biology, 2004
A new optical trapping study shows that the stepsize of cytoplasmic dynein varies according to the applied force, suggesting that this motor can change gear. Complementary biochemical kinetic work on yeast dynein mutants hints at the allosteric mechanisms involved.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source