Results 31 to 40 of about 4,835,014 (147)

The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows

iScience
Summary: Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions,
Rodrigo Zúñiga Mouret, Jordyn P. Greenbaum, Hannah M. Doll, Eliza M. Brody, Emma L. Iacobucci, Nicholas C. Roland, Roy C. Simamora, Ivan Ruiz, Rory Seymour, Leanne Ludwick, Jacob A. Krawitz, Antonia H. Groneberg, João C. Marques, Alexandre Laborde, Gokul Rajan, Filippo Del Bene, Michael B. Orger, Roshan A. Jain   +17 more
doaj   +1 more source

TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex

iScience
Summary: Individuals within the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD) often experience disruptive mental behaviors and sleep-wake disturbances.
Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang   +3 more
doaj   +1 more source

ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling

iScience
Summary: Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking.
Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozzi   +9 more
doaj   +1 more source

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

iScience
Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects
Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese   +14 more
doaj   +1 more source

Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons

iScience, 2019
Summary: Precise regulation of neuronal migration termination is crucial for the establishment of brain cytoarchitectures. However, little is known about how neurons terminate migration.
Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata   +8 more
doaj   +1 more source

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

iScience, 2022
Summary: The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms.
Qiaocheng Zhai, Yizhun Zeng, Yue Gu, Zhihao Li, Tao Zhang, Baoshi Yuan, Tao Wang, Jie Yan, Han Qin, Ling Yang, Xiaowei Chen, Antonio Vidal-Puig, Ying Xu   +12 more
doaj   +1 more source

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

iScience, 2021
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated.
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke   +9 more
doaj   +1 more source

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source

Neuroscience of alcoholism: molecular and cellular mechanisms [PDF]

Cellular and Molecular Life Sciences, 2009
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of
Sachin, Moonat, Bela G, Starkman, Amul, Sakharkar, Subhash C, Pandey   +3 more
openaire   +2 more sources

BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines

iScience
Summary: Synaptic structural plasticity, the expansion of dendritic spines in response to synaptic stimulation, is essential for experience-dependent plasticity and is driven by branched actin polymerization. The WAVE regulatory complex (WRC) is confined
Belal Shohayeb, Kai Sempert, Tristan P. Wallis, Frédéric A. Meunier, Nela Durisic, Elizabeth A. O'Brien, Cecilia Flores, Helen M. Cooper   +7 more
doaj   +1 more source