Results 31 to 40 of about 4,441,106 (313)
Structural basis for SARM1 inhibition and activation under energetic stress
eLife, 2020 SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present
Michael Sporny +10 more
doaj +1 more source
Gain control in molecular information processing: Lessons from neuroscience [PDF]
, 2011 Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain control.
Berg H +6 more
core +1 more source
Super-resolving Microscopy in Neuroscience.
Chemical Reviews, 2021 Fluorescence imaging techniques play a pivotal role in our understanding of the nervous system. The emergence of various super-resolution microscopy methods and specialized fluorescent probes enables direct insight into neuronal structure and protein ...
Christian Werner, M. Sauer, C. Geis
semanticscholar +1 more source
iScience, 2021 Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair +8 more
doaj +1 more source
iScience, 2022 Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen +9 more
doaj +1 more source
World Journal of Psychiatry, 2021 Psychiatry remains in a permanent state of crisis, which fragmented psychiatry from the field of medicine. The crisis in psychiatry is evidenced by the many different competing approaches to psychiatric illness including psychodynamic, biological ...
D. Stoyanov, M. Maes
semanticscholar +1 more source
Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
iScience, 2022 Summary: Targeted therapies for epilepsies associated with the mTORC1 signaling negative regulator GATOR1 are lacking. NPRL2 is a subunit of the GATOR1 complex and mutations in GATOR1 subunits, including NPRL2, are associated with epilepsy.
Brianne Dentel +11 more
doaj +1 more source
iScience, 2019 Summary: Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with ...
Luye Qin, Kaijie Ma, Zhen Yan
doaj +1 more source
The Dichotomous Role of Extracellular Vesicles in the Central Nervous System
iScience, 2020 Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest in the role of central nervous system (CNS)-derived EVs has been increasing; however, some skepticism of their importance has persisted because many ...
David R. Graykowski +3 more
doaj +1 more source
An Affective Neuroscience Framework for the Molecular Study of Internet Addiction
Frontiers in Psychology, 2016 Internet addiction represents an emerging global health issue. Increasing efforts have been made to characterize risk factors for the development of Internet addiction and consequences of excessive Internet use.
C. Montag +3 more
semanticscholar +1 more source