Results 31 to 40 of about 4,488,559 (341)

Spatial transcriptomics in neuroscience

Experimental and Molecular Medicine, 2023
The brain is one of the most complex living tissue types and is composed of an exceptional diversity of cell types displaying unique functional connectivity.
Namyoung Jung, Tae-Kyung Kim
semanticscholar   +1 more source

Unifying the essential concepts of biological networks: biological insights and philosophical foundations [PDF]

, 2020
Over the last decades, network-based approaches have become highly popular in diverse fields of biology, including neuroscience, ecology, molecular biology and genetics.
Hilgetag, Claus, Kostic, Daniel, Tittgemeyer, Marc   +2 more
core   +2 more sources

Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective

International Journal of Molecular Sciences, 2023
Human neuroimaging has demonstrated the existence of large-scale functional networks in the cerebral cortex consisting of topographically distant brain regions with functionally correlated activity.
Adriana K. Cushnie, Wei-jun Tang, Sarah R. Heilbronner   +2 more
semanticscholar   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source

Structural basis for SARM1 inhibition and activation under energetic stress

eLife, 2020
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present
Michael Sporny, Julia Guez-Haddad, Tami Khazma, Avraham Yaron, Moshe Dessau, Yoel Shkolnisky, Carsten Mim, Michail N Isupov, Ran Zalk, Michael Hons, Yarden Opatowsky   +10 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Super-resolving Microscopy in Neuroscience.

Chemical Reviews, 2021
Fluorescence imaging techniques play a pivotal role in our understanding of the nervous system. The emergence of various super-resolution microscopy methods and specialized fluorescent probes enables direct insight into neuronal structure and protein ...
Christian Werner, M. Sauer, C. Geis
semanticscholar   +1 more source

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

iScience, 2022
Summary: The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms.
Qiaocheng Zhai, Yizhun Zeng, Yue Gu, Zhihao Li, Tao Zhang, Baoshi Yuan, Tao Wang, Jie Yan, Han Qin, Ling Yang, Xiaowei Chen, Antonio Vidal-Puig, Ying Xu   +12 more
doaj   +1 more source

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

iScience, 2021
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated.
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke   +9 more
doaj   +1 more source

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source