Results 41 to 50 of about 4,381,034 (355)

How to construct neuroscience-informed psychiatric classification? Towards nomothetic networks psychiatry

World Journal of Psychiatry, 2021
Psychiatry remains in a permanent state of crisis, which fragmented psychiatry from the field of medicine. The crisis in psychiatry is evidenced by the many different competing approaches to psychiatric illness including psychodynamic, biological ...
D. Stoyanov, M. Maes
semanticscholar   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source

An Affective Neuroscience Framework for the Molecular Study of Internet Addiction

Frontiers in Psychology, 2016
Internet addiction represents an emerging global health issue. Increasing efforts have been made to characterize risk factors for the development of Internet addiction and consequences of excessive Internet use.
C. Montag, C. Sindermann, B. Becker, J. Panksepp   +3 more
semanticscholar   +1 more source

Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation

iScience, 2019
Summary: Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with ...
Luye Qin, Kaijie Ma, Zhen Yan
doaj   +1 more source

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

iScience, 2022
Summary: The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms.
Qiaocheng Zhai, Yizhun Zeng, Yue Gu, Zhihao Li, Tao Zhang, Baoshi Yuan, Tao Wang, Jie Yan, Han Qin, Ling Yang, Xiaowei Chen, Antonio Vidal-Puig, Ying Xu   +12 more
doaj   +1 more source

Knowing one's place: a free-energy approach to pattern regulation. [PDF]

, 2015
Understanding how organisms establish their form during embryogenesis and regeneration represents a major knowledge gap in biological pattern formation.
Friston, K, Levin, M, Pezzulo, G, Sengupta, B   +3 more
core   +1 more source

Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons

iScience, 2019
Summary: Precise regulation of neuronal migration termination is crucial for the establishment of brain cytoarchitectures. However, little is known about how neurons terminate migration.
Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata   +8 more
doaj   +1 more source

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

iScience, 2021
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated.
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke   +9 more
doaj   +1 more source

The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows

iScience
Summary: Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions,
Rodrigo Zúñiga Mouret, Jordyn P. Greenbaum, Hannah M. Doll, Eliza M. Brody, Emma L. Iacobucci, Nicholas C. Roland, Roy C. Simamora, Ivan Ruiz, Rory Seymour, Leanne Ludwick, Jacob A. Krawitz, Antonia H. Groneberg, João C. Marques, Alexandre Laborde, Gokul Rajan, Filippo Del Bene, Michael B. Orger, Roshan A. Jain   +17 more
doaj   +1 more source