Results 41 to 50 of about 4,835,014 (147)

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

iScience, 2021
Summary: Brain development is a highly orchestrated process requiring spatiotemporally regulated mitochondrial dynamics. Drp1, a key molecule in the mitochondrial fission machinery, undergoes various post-translational modifications including conjugation
Seiya Yamada, Ayaka Sato, Naotada Ishihara, Hiroki Akiyama, Shin-ichi Sakakibara   +4 more
doaj   +1 more source

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

iScience, 2021
Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the ...
Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen   +4 more
doaj   +1 more source

Cytosolic dopamine determines hypersensitivity to blunt force trauma

iScience
Summary: The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans.
Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L.B. Arneaud, Lexus Tatge, Gupse Otuzoglu, Jordan M. Wall, Peter M. Douglas   +6 more
doaj   +1 more source

Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma

iScience, 2023
Summary: Interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and Müller cells in retina neurodegenerations like glaucoma. This study focuses on
Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhong   +9 more
doaj   +1 more source

Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls

iScience
Summary: There is an unmet need for objective disease-specific biomarkers in the heterogeneous autoimmune neuromuscular disorder myasthenia gravis (MG).
Amol K. Bhandage, Viktorija Kenina, Yu-Fang Huang, Marija Roddate, Gundega Kauke, Arta Grosmane, Violeta Žukova, Niclas Eriksson, Katja Gabrysch, Tanel Punga, Anna Rostedt Punga   +10 more
doaj   +1 more source

Aptamers as Valuable Molecular Tools in Neurosciences [PDF]

The Journal of Neuroscience, 2017
Aptamers are short nucleic acids that interact with a variety of targets with high affinity and specificity. They have been shown to inhibit biological functions of cognate target proteins, and they are identifiable by anin vitroselection process, also termed SELEX (Systematic Evolution of Ligands by EXponential enrichment).
Olga, Wolter, Günter, Mayer
openaire   +2 more sources

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

iScience, 2020
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen   +11 more
doaj   +1 more source

Chronic modulation of cAMP signaling elicits synaptic scaling irrespective of activity

iScience
Summary: Homeostatic plasticity mechanisms act in a negative feedback manner to stabilize neuronal firing around a set point. Classically, homeostatic synaptic plasticity is elicited via rather drastic manipulation of activity in a neuronal population ...
Elena D. Bagatelas, Ege T. Kavalali
doaj   +1 more source

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism

iScience
Summary: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype ...
Allison Y. Louie, Jenny Drnevich, Jennifer L. Johnson, Meagan Woodard, Anna V. Kukekova, Rodney W. Johnson, Andrew J. Steelman   +6 more
doaj   +1 more source

NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14

iScience
Summary: The blood-nerve-barrier (BNB) that regulates peripheral nerve homeostasis is formed by endoneurial capillaries and perineurial cells surrounding the Schwann cell (SC)-rich endoneurium.
Jennifer Patritti-Cram, Eric P. Rahrmann, Tilat A. Rizvi, Katherine C. Scheffer, Timothy N. Phoenix, David A. Largaespada, Nancy Ratner   +6 more
doaj   +1 more source