Results 61 to 70 of about 4,381,034 (355)

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations

iScience, 2023
Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain ...
Yinghua Qu, Jonathan Jun-Yong Lim, Omer An, Henry Yang, Yi-Chin Toh, John Jia En Chua   +5 more
doaj   +1 more source

Combining Animal Welfare With Experimental Rigor to Improve Reproducibility in Behavioral Neuroscience

Frontiers in Behavioral Neuroscience, 2021
1 Molecular and Behavioral Neuroscience Laboratory, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil, 2 National Institute for Translational Medicine (INCT-TM), National Council for Scientific and Technological ...
C. Loss, F. F. Melleu, K. Domingues, C. Lino-de-Oliveira, G. Viola   +4 more
semanticscholar   +1 more source

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

iScience
Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects
Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese   +14 more
doaj   +1 more source

Aptamers as Valuable Molecular Tools in Neurosciences [PDF]

The Journal of Neuroscience, 2017
Aptamers are short nucleic acids that interact with a variety of targets with high affinity and specificity. They have been shown to inhibit biological functions of cognate target proteins, and they are identifiable by anin vitroselection process, also termed SELEX (Systematic Evolution of Ligands by EXponential enrichment).
Günter Mayer, Olga Wolter
openaire   +2 more sources

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

FEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source

BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines

iScience
Summary: Synaptic structural plasticity, the expansion of dendritic spines in response to synaptic stimulation, is essential for experience-dependent plasticity and is driven by branched actin polymerization. The WAVE regulatory complex (WRC) is confined
Belal Shohayeb, Kai Sempert, Tristan P. Wallis, Frédéric A. Meunier, Nela Durisic, Elizabeth A. O'Brien, Cecilia Flores, Helen M. Cooper   +7 more
doaj   +1 more source

Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region

iScience, 2023
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu   +6 more
doaj   +1 more source

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis [PDF]

, 2013
Although mutations in the huntingtin gene (HTT) due to poly-Q expansion cause neuropathology in humans (Huntington's disease; HD), the normal function(s) of the gene and its protein (HTT) remain obscure.
Brown, Euan R., Idris, Mohammed M, Thorndyke, Michael C   +2 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

iScience, 2020
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen   +11 more
doaj   +1 more source