Results 71 to 80 of about 4,488,559 (341)

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

iScience, 2021
Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the ...
Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen   +4 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Cytosolic dopamine determines hypersensitivity to blunt force trauma

iScience
Summary: The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans.
Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L.B. Arneaud, Lexus Tatge, Gupse Otuzoglu, Jordan M. Wall, Peter M. Douglas   +6 more
doaj   +1 more source

Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma

iScience, 2023
Summary: Interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and Müller cells in retina neurodegenerations like glaucoma. This study focuses on
Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhong   +9 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls

iScience
Summary: There is an unmet need for objective disease-specific biomarkers in the heterogeneous autoimmune neuromuscular disorder myasthenia gravis (MG).
Amol K. Bhandage, Viktorija Kenina, Yu-Fang Huang, Marija Roddate, Gundega Kauke, Arta Grosmane, Violeta Žukova, Niclas Eriksson, Katja Gabrysch, Tanel Punga, Anna Rostedt Punga   +10 more
doaj   +1 more source

Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]

, 2014
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J, Froemke, Robert C, Gomez, Andrea M   +2 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

MU Neurobehavioral Core Facility: Progressing from Molecules to Behavior [PDF]

, 2010
Neuroscience - Vision & Functional Brain Imaging Poster SessionAn important component of modern neuroscience research is the ability to measure systematically and objectively different aspects of behavior.
Miller, Dennis K. (Dennis Keith), Simonyi, Agnes   +1 more
core  

Psychoanalysis and neurosciences: fuzzy outlines? Notes on the notion of cerebral plasticity [PDF]

, 2017
“Psychoanalysis versus psychiatry” and “unconscious versus brain” are classic oppositions between different perspectives on the human being and mental suffering.
Mantilla, Maria Jimena
core   +1 more source