Results 71 to 80 of about 4,381,034 (355)

Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress

iScience, 2022
Summary: While schizophrenia pathogenesis involves both genetic and environmental factors, their specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven BDNF expression, combined with early-life adversity, results in ...
Yanhui Chen, Shangjin Li, Tianyi Zhang, Feng Yang, Bai Lu   +4 more
doaj   +1 more source

Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium [PDF]

, 2019
Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases.
Adams, H., Ahmad, S., Ames, D., Amin, N., Amouye, P., Andreassen, O., Armstrong, N., Bastin, M., Becker, J., Beiser, A., Bernard, M., Beyer, F., Bis, J., Bralten, J., Brodaty, H., Bülow, R., Carmichael, O., Colodro-Conde, L., Crivello, F., Dale, A., Deary, I., Debette, S., DeCarli, C., Fornage, M., Franz, C., Gillespie, N., Grabe, H., Grasby, K., Harris, M., Hibar, D., Himali, J., Hofer, E., Hofman, A., Ikram, M., Jahanshad, N., Jian, X., Jiang, J., Karama, S., Knol, M., Kremen, W., Kwok, J., Lewis, L., Li, S., Lin, H., Lind, P., Loeffler, M., Logue, M., Longstreth Jr., W., Lopez, O., Luciano, M., Lyons, M., Maillard, P., Maingault, S., Mather, K., Mazoyer, B., Medland, S., Mishra, A., Mosley, T., Neale, M., Niessen, W., Painter, J., Panizzon, M., Paus, T., Pausova, Z., Pike, G., Pirpamer, L., Pizzagalli, F., Psaty, B., Roshchupkin, G., Rotter, J., Saba, Y., Sachdev, P., Satizabal, C., Schmid, R., Schmidt, H., Schofield, P., Scholz, M., Seiler, S., Seshadr, S., Stein, J., Teumer, A., Thalamuthu, A., Thompson, P., Trollor, J., Tzourio, C., Uitterlinden, A., van der Lee, S., van Duijn, C., Vernooij, M., Villringer, A., Völker, U., Wardlaw, J., Wen, W., Witte, A., Wittfeld, K., Wright, M., Xia, R., Yang, Q., Zare, H.   +98 more
core   +2 more sources

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Memory rescue and learning in synaptic impaired neuronal circuits

iScience, 2023
Summary: Neuronal impairment is a characteristic of Alzheimer’s disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear.
Kwan Tung Li, Daoyun Ji, Changsong Zhou
doaj   +1 more source

The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. [PDF]

, 2015
The neural activity patterns of suprachiasmatic nucleus (SCN) neurons are dynamically regulated throughout the circadian cycle with highest levels of spontaneous action potentials during the day.
Block, Gene D, Colwell, Christopher S, Kudo, Takashi   +2 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Cytosolic dopamine determines hypersensitivity to blunt force trauma

iScience
Summary: The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans.
Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L.B. Arneaud, Lexus Tatge, Gupse Otuzoglu, Jordan M. Wall, Peter M. Douglas   +6 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls

iScience
Summary: There is an unmet need for objective disease-specific biomarkers in the heterogeneous autoimmune neuromuscular disorder myasthenia gravis (MG).
Amol K. Bhandage, Viktorija Kenina, Yu-Fang Huang, Marija Roddate, Gundega Kauke, Arta Grosmane, Violeta Žukova, Niclas Eriksson, Katja Gabrysch, Tanel Punga, Anna Rostedt Punga   +10 more
doaj   +1 more source