Results 71 to 80 of about 4,441,106 (313)

Cytosolic dopamine determines hypersensitivity to blunt force trauma

iScience
Summary: The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans.
Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L.B. Arneaud, Lexus Tatge, Gupse Otuzoglu, Jordan M. Wall, Peter M. Douglas   +6 more
doaj   +1 more source

2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals [PDF]

, 2017
Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects in many models of this disease ...
Gaveglio, Virginia Lucía, Giusto, Norma Maria, Pascual, Ana Clara, Pasquaré, Susana Juana   +3 more
core   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls

iScience
Summary: There is an unmet need for objective disease-specific biomarkers in the heterogeneous autoimmune neuromuscular disorder myasthenia gravis (MG).
Amol K. Bhandage, Viktorija Kenina, Yu-Fang Huang, Marija Roddate, Gundega Kauke, Arta Grosmane, Violeta Žukova, Niclas Eriksson, Katja Gabrysch, Tanel Punga, Anna Rostedt Punga   +10 more
doaj   +1 more source

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]

, 2016
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted, Aton, Sara J., Baillie, George S., Bruinenberg, Vibeke M., Day, Jonathan P., Ferri, Sarah L., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Luczak, Vincent G., Meerlo, Peter, Park, Alan J., Poplawski, Shane G., Radwanska, Kasia, Tudor, Jennifer C.   +14 more
core   +5 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

iScience, 2021
Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the ...
Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen   +4 more
doaj   +1 more source

MU Neurobehavioral Core Facility: Progressing from Molecules to Behavior [PDF]

, 2010
Neuroscience - Vision & Functional Brain Imaging Poster SessionAn important component of modern neuroscience research is the ability to measure systematically and objectively different aspects of behavior.
Miller, Dennis K. (Dennis Keith), Simonyi, Agnes   +1 more
core  

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma

iScience, 2023
Summary: Interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and Müller cells in retina neurodegenerations like glaucoma. This study focuses on
Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhong   +9 more
doaj   +1 more source