Results 1 to 10 of about 363,849 (261)

Experimental training in molecular pharmacology education based on drug–target interactions [PDF]

open access: yesPharmacology Research & Perspectives, 2023
Introduction Drug development has been challenged by the dual drawbacks involving unpredictable disease outcomes and drug resistance, which has placed greater demands on pharmacology education.
Luna Ge   +6 more
doaj   +2 more sources

Molecular Pharmacology in Diabetes. [PDF]

open access: yesInt J Mol Sci
This Special Issue highlights the key molecules and molecular signaling pathways associated with diabetes and its multifaceted complications [...]
Reis F, Fernandes R.
europepmc   +3 more sources

Molecular Pharmacology at the Crossroads of Precision Medicine [PDF]

open access: yesCurrent Issues in Molecular Biology
Molecular pharmacology sits at the nexus of fundamental molecular science and therapeutic innovation [...]
Alina Crenguţa Nicolae   +2 more
doaj   +2 more sources

Molecular pharmacology of GPCRs. [PDF]

open access: yesBr J Pharmacol, 2018
Linked ArticlesThis article is part of a themed section on Molecular Pharmacology of GPCRs. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.21 ...
Langmead CJ, Summers RJ.
europepmc   +4 more sources

Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance [PDF]

open access: yesTropical Medicine and Infectious Disease, 2019
The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely understood. Clinically, these drugs are used in combination with longer lasting partner drugs in several different artemisinin combination therapies (ACTs). ACTs are
Laura E. Heller, Paul D. Roepe
doaj   +2 more sources

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

open access: yesFrontiers in Pharmacology, 2022
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt   +10 more
doaj   +1 more source

Transcriptional Activation, Deactivation and Rebound Patterns in Cortex, Hippocampus and Amygdala in Response to Ketamine Infusion in Rats

open access: yesFrontiers in Molecular Neuroscience, 2022
Ketamine, an N-methyl-D-aspartate (NMDA)-receptor antagonist, is a recently revitalized treatment for pain and depression, yet its actions at the molecular level remain incompletely defined.
Jenny J. Kim   +8 more
doaj   +1 more source

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

open access: yesCells, 2022
The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh   +3 more
doaj   +1 more source

Systematic analysis of molecular biological mechanisms for supporting connective tissue metabolism with chondroitin sulfate

open access: yesНеврология, нейропсихиатрия, психосоматика, 2021
Objective: to analyze the roles of undifferentiated connective tissue dysplasia (UCTD) in the development of cartilage and ligamentous apparatus diseases.Material and methods. This paper presents the results of analyzing the literature on fundamental and
I. Yu. Torshin   +4 more
doaj   +1 more source

Decoding the mechanisms of allostery

open access: yeseLife, 2023
A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
Saif Khan, Cornelius Gati
doaj   +1 more source

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