Results 21 to 30 of about 363,849 (261)

On the role of glycogen synthase kinases in the molecular mechanisms of stress conditions and prospects for the use of lithium ascorbate

Неврология, нейропсихиатрия, психосоматика, 2022
It is well known that a complex of nervous and hormonal signals during stress stimulates adrenal glands to secrete adrenaline, norepinephrine and cortisol.
I. Yu. Torshin, O. A. Gromova, O. A. Limanova   +2 more
doaj   +1 more source

Chemotranscriptome analysis of the ethylmethylhydroxypyridine succinate molecule in the context of postgenomic pharmacology

Неврология, нейропсихиатрия, психосоматика, 2020
Postgenomic pharmacology deals with the desirable and undesirable effects of drugs in relation to the genome, transcriptome, proteome, and reactome.
O. A. Gromova, I. Yu. Torshin, A. I. Sorokin, V. A. Semenov, L. V. Stakhovskaya   +4 more
doaj   +1 more source

A Comparative Study of Systems Pharmacology and Gene Chip Technology for Predicting Targets of a Traditional Chinese Medicine Formula in Primary Liver Cancer Treatment

Frontiers in Pharmacology, 2022
Background: The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this model to other prediction models is yet to be established.Objective:
Songzhe Li, Yang Sun, Yue Sun
doaj   +1 more source

Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation

iScience, 2023
Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li, Jian-Rong Shi, Shu-Chan Li, Lu-Ming Wang, Rana Dhar, Ning Li, Xin-Wei Cao, Zi-Gang Li, Hui-Fang Tang   +8 more
doaj   +1 more source

Molecular Clocks in Pharmacology [PDF]

, 2013
Circadian rhythms regulate a vast array of biological processes and play a fundamental role in mammalian physiology. As a result, considerable diurnal variation in the pharmacokinetics, efficacy, and side effect profiles of many therapeutics has been described.
Erik S, Musiek, Garret A, Fitzgerald
openaire   +2 more sources

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling

iScience, 2023
Summary: Overdose acetaminophen (APAP) can cause acute liver injury (ALI), but the underlying mechanism remains undetermined. This study explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against APAP-mediated ...
Yingjian Chen, Tianqi Cui, Shaorong Xiao, Tianyao Li, Yadi Zhong, Kaijia Tang, Jingyi Guo, Shangyi Huang, Jiabing Chen, Jiayu Li, Qi Wang, Jiawen Huang, Huafeng Pan, Yong Gao   +13 more
doaj   +1 more source

Neurotrophic and antioxidant potential of neuropeptides and trace elements

Неврология, нейропсихиатрия, психосоматика, 2016
Neurotrophic therapy with brain extract-based drugs has been performed for decades. The basis for their neurotrophic activity is amino acids and neuropeptides.
O. A. Gromova, A. V. Pronin, I. Yu. Torshin, A. G. Kalacheva, T. R. Grishina   +4 more
doaj   +1 more source

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

eLife
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) regulates transcription in response to ligand binding at an orthosteric pocket within the ligand-binding domain (LBD).
Liudmyla Arifova, Brian S MacTavish, Zane Laughlin, Mithun Nag Karadi Girdhar, Jinsai Shang, Min-Hsuan Li, Xiaoyu Yu, Di Zhu, Theodore M Kamenecka, Douglas J Kojetin   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Establishment and evaluation of melanoma model

Journal of Hebei University of Science and Technology, 2018
In order to screen drug rapidly and effectively in vivo, the approach of the establishment for mouse melanoma model with primary cell from melanin solid tumor tissue of mouse is studied.
Xiangli YAO, Xuguang MIAO, Xixi WEI, Xuan WANG, Shouxin LIU   +4 more
doaj   +1 more source