Results 11 to 20 of about 6,842,401 (297)
Molecular imaging with engineered physiology
Nature Communications, 2016 The vasculature produces strong endogenous contrast in magnetic resonance imaging (MRI). Here Desai et al. report genetically encoded imaging probes derived from the vasodilator, calcitonin gene-related peptide, which allows visualization of molecular ...
Mitul Desai +4 more
doaj +5 more sources
Molecular physiology and pathophysiology of stromal interaction molecules. [PDF]
Exp Biol Med (Maywood), 2018 Nelson HA, Roe MW.
europepmc +2 more sources
TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells
iScience, 2021 Summary: This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis
Faye Wang +12 more
doaj +1 more source
Molecular Physiology of TRPV Channels: Controversies and Future Challenges.
Annual Review of Physiology, 2023 The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs.
T. Rosenbaum, L. Islas
semanticscholar +1 more source
Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue
iScience, 2022 Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure ...
Yohko Yoshida +9 more
doaj +1 more source
Impaired interferon-γ signaling promotes the development of silicosis
iScience, 2022 Summary: Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility.
Zhouyangfan Peng +13 more
doaj +1 more source
iScience, 2023 Summary: Cataract is the leading cause of blindness worldwide. Here, we reported a potential, effective therapeutic mean for cataract prevention and treatment.
Yu Du +6 more
doaj +1 more source
Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain
iScience, 2022 Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan +9 more
doaj +1 more source
Renal neoplasms in tuberous sclerosis mice are neurocristopathies
iScience, 2021 Summary: Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS ...
Uchenna Unachukwu +4 more
doaj +1 more source
iScience, 2022 Summary: Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how these phenotypic differences are established.
Carlos F.H. Serra +5 more
doaj +1 more source