Results 21 to 30 of about 6,842,401 (297)

Molecular regulations of circadian rhythm and implications for physiology and diseases

Signal Transduction and Targeted Therapy, 2022
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period associated with the earth’s daily rotation and light/dark cycle.
F. Fagiani, D. Di Marino, A. Romagnoli, C. Travelli, Davide Voltan, L. di Cesare Mannelli, M. Racchi, S. Govoni, C. Lanni   +8 more
semanticscholar   +1 more source

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations

iScience, 2022
Summary: Very few drugs in clinical practice feature the chemical diversity, narrow therapeutic window, unique route of administration, and reversible cognitive effects of volatile anesthetics.
Eric A. Zizzi, Marco Cavaglià, Jack A. Tuszynski, Marco A. Deriu   +3 more
doaj   +1 more source

A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

iScience, 2021
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks in the head and neck, making surgery challenging.
Erdem Bangi, Peter Smibert, Andrew V. Uzilov, Alexander G. Teague, Sindhura Gopinath, Yevgeniy Antipin, Rong Chen, Chana Hecht, Nelson Gruszczynski, Wesley J. Yon, Denis Malyshev, Denise Laspina, Isaiah Selkridge, Huan Wang, Jorge Gomez, John Mascarenhas, Aye S. Moe, Chun Yee Lau, Patricia Taik, Chetanya Pandya, Max Sung, Sara Kim, Kendra Yum, Robert Sebra, Michael Donovan, Krzysztof Misiukiewicz, Celina Ang, Eric E. Schadt, Marshall R. Posner, Ross L. Cagan   +29 more
doaj   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source

The molecular athlete: exercise physiology from mechanisms to medals

Physiological Reviews, 2023
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external stimuli including the habitual level of contractile loading. Accordingly, muscle function and exercise capacity encompass a broad spectrum, from inactive individuals ...
R. Furrer, J. Hawley, Christoph Handschin   +2 more
semanticscholar   +1 more source

Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

Pharmacological Reviews, 2022
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are proteases capable of remodeling the extracellular matrix.
Luiz G. N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, D. Young, S. Gill, L. Devel, A. Dufour   +7 more
semanticscholar   +1 more source

Molecular Physiology of Bile Acid Signaling in Health, Disease and Aging.

Physiological Reviews, 2020
Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut ...
A. Perino, H. Demagny, Laura A. Velazquez-Villegas, K. Schoonjans   +3 more
semanticscholar   +1 more source

NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

Antioxidants, 2021
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first identified in the membrane of phagocytic cells. For many years, its only known role was in immune defense, where its ROS production leads to the destruction of pathogens by ...
Annelise Vermot, Isabelle Petit-Härtlein, Susan M E Smith, F. Fieschi   +3 more
semanticscholar   +1 more source

Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn.

Physiological Reviews, 2020
Bilirubin is the end product of heme catabolism formed during a process that involves oxidation-reduction reactions and conserves iron body stores. Unconjugated hyperbilirubinemia is common in newborn infants, but rare later in life. The basic physiology
T. Hansen, R. Wong, D. Stevenson
semanticscholar   +1 more source

Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice

iScience, 2021
Summary: Cardiac hypertrophy is an adaptive response to all forms of heart disease, including hypertension, myocardial infarction, and cardiomyopathy. Cyclooxygenase-2 (COX-2) overexpression results in inflammatory response, cardiac cell apoptosis, and ...
Yanli Zhao, Qi Zheng, Hanchao Gao, Mengtao Cao, Huiyun Wang, Rong Chang, Changchun Zeng   +6 more
doaj   +1 more source